| Nicotine metabolism in healthy smokers and patients with cardiovascular diseases. | |
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MedLine Citation:
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PMID: 16311929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we measured the excretion rate of nicotine and its two major metabolites, cotinine and trans-3'-hydroxycotinine (THOC), in the urine of 25 healthy smokers and 15 smokers who underwent a coronary artery bypass surgery or coronary angioplasty. After 1 day of smoking cessation, urine samples were collected in the morning, before smoking two cigarettes, and then three times after smoking, approximately 4 h apart. The results show that (i) in healthy smokers, nicotine and its two major metabolites were present at high concentration in the first urine sample after smoking, (ii) in smokers with cardiovascular disease nicotine and cotinine were less excreted whereas THOC was more excreted, mainly in the second urine sample. We conclude that this shift in nicotine metabolism may contribute to smoking-induced cardiovascular disease. |
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Authors:
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Ramez Chahine; Antoine Abchee; Pierre Zalloua |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Molecular and cellular biochemistry Volume: 280 ISSN: 0300-8177 ISO Abbreviation: Mol. Cell. Biochem. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2005-11-28 Completed Date: 2006-04-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0364456 Medline TA: Mol Cell Biochem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 241-4 Citation Subset: IM |
Affiliation:
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Laboratory of Physiology, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon. rchahine@lb.refer.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cardiovascular Diseases / metabolism* Case-Control Studies Cotinine / urine Health Humans Male Middle Aged Nicotine / metabolism*, urine Smoking / metabolism* |
| Chemical | |
Reg. No./Substance:
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486-56-6/Cotinine; 54-11-5/Nicotine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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