Document Detail


Nicotine induced ovarian and uterine changes in albino mice.
MedLine Citation:
PMID:  10874351     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nicotine at the dose level of 0.3 mg/100 g body weight was administered to normal cycling mice for 15 days through oral and intraperitoneal routes. At autopsy on 16th day significant reduction in the ovarian and uterine weight was observed. Histological observations showed decrease in the number and size of Graafian follicles, corpora lutea and increase in the atretic follicles in the ovary. The uterus showed absence of endometrial glands, decrease in the height of myometrium, endometrium and its epithelial cells. The total cholesterol content of the ovary and uterus is increased whereas the protein content is decreased. This antagonistic action of nicotine to gonadotrophins is discussed.
Authors:
S R Patil; Ravindra; S R Patil; R Londonkar; S B Patil
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  42     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  503-8     Citation Subset:  IM    
Affiliation:
Department of Zoology, Gulbarga University.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cholesterol / analysis,  physiology
Female
Mice
Nicotine / pharmacology*
Nicotinic Agonists / pharmacology*
Organ Size / drug effects,  physiology
Ovary / drug effects*,  physiology
Proteins / analysis,  physiology
Uterus / drug effects*,  physiology
Chemical
Reg. No./Substance:
0/Nicotinic Agonists; 0/Proteins; 54-11-5/Nicotine; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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