Document Detail

Nicotine-evoked conditioned responding is dependent on concentration of sucrose unconditioned stimulus.
MedLine Citation:
PMID:  19429207     Owner:  NLM     Status:  MEDLINE    
Previous studies have shown that the interoceptive nicotine conditional stimulus (CS) functions similarly to exteroceptive CSs such as lights or environments. For instance, the appetitive conditioned response (CR) evoked when nicotine is repeatedly paired with sucrose presentations (the unconditioned stimulus; US) is sensitive to changes in training dose (CS salience) and the contiguity between the CS effects and sucrose. The current study was conducted to extend this research by examining the possible role of US intensity in CR acquisition and maintenance. Rats were trained using one of four sucrose concentrations: 0, 4, 16, or 32% (w/v). On nicotine sessions (0.4 mg base/kg), rats received 36 deliveries (4s each) of their assigned concentration intermittently throughout the session; sucrose was withheld on saline sessions. In all groups, an appetitive goal-tracking CR was acquired at a similar rate. However, the asymptotic CR level varied with sucrose concentration. The magnitude of the CR was increased in rats trained with higher sucrose US concentrations. These findings are consistent with previous Pavlovian conditioning research, and extend the conditions under which the nicotine state functions as an interoceptive conditional stimulus.
Jennifer E Murray; Rachel D Penrod; Rick A Bevins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-01-17
Journal Detail:
Title:  Behavioural processes     Volume:  81     ISSN:  1872-8308     ISO Abbreviation:  Behav. Processes     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-11     Completed Date:  2009-08-13     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  7703854     Medline TA:  Behav Processes     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  136-9     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Conditioning, Classical / drug effects*
Dietary Sucrose / administration & dosage*
Discrimination Learning / drug effects
Drinking Behavior
Nicotine / administration & dosage*
Nicotinic Agonists / administration & dosage*
Random Allocation
Rats, Sprague-Dawley
Reinforcement (Psychology)*
Grant Support
DA018114/DA/NIDA NIH HHS; DA025399/DA/NIDA NIH HHS; R01 DA018114/DA/NIDA NIH HHS; R01 DA018114-03/DA/NIDA NIH HHS; R01 DA018114-04/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dietary Sucrose; 0/Nicotinic Agonists; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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