Document Detail

Nicotine does not influence arterial lipid deposits in rabbits exposed to second-hand smoke.
MedLine Citation:
PMID:  11502707     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Second-hand smoke (SHS) accelerates atherogenesis and impairs vascular function. The role of nicotine in this process has not been defined. METHODS AND RESULTS: To examine the potential effects of nicotine on atherogenesis and vascular function, 48 rabbits receiving a 0.5% cholesterol diet were randomized to control (cholesterol diet only), SHS from nicotine-standard research cigarettes (SHS-ST), and SHS from nicotine-free research cigarettes (SHS-NF). The SHS rabbits were exposed to 48 nicotine-standard (12 animals) or nicotine-free (12 animals) cigarettes/d, 5 d/wk for 10 weeks. Air carbon monoxide and particulates and plasma carboxyhemoglobin were significantly higher in the 2 SHS groups than the control group (P<0.001). The SHS-ST group had significant increases in plasma nicotine and cotinine compared with the other groups (P<0.001). There was no difference in serum lipids. Lipid lesions were increased in both SHS groups (54+/-5% [SEM] aorta and 66+/-4% pulmonary artery, 53+/-7% and 69+/-4%, and 39+/-4% and 43+/-3% in the SHS-ST, SHS-NF, and control groups, respectively; P=0.049 aorta and P<0.001 pulmonary artery). CONCLUSIONS: SHS exposure increased arterial lipid lesions, but nicotine did not contribute significantly to this effect. This effect is presumably due to other combustion products in the smoke.
Y P Sun ; B Q Zhu; A E Browne; R E Sievers; J M Bekker; K Chatterjee; W W Parmley; S A Glantz
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  104     ISSN:  1524-4539     ISO Abbreviation:  Circulation     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-14     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  810-4     Citation Subset:  AIM; IM    
Division of Cardiology, Department of Medicine and the Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143, USA.
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MeSH Terms
Aorta / drug effects,  pathology
Arteriosclerosis / blood,  etiology*,  pathology
Cotinine / blood
Diet, Atherogenic
Disease Progression
Lipids / blood
Nicotine / blood,  pharmacology*
Pulmonary Artery / drug effects,  pathology
Tobacco Smoke Pollution / adverse effects*
Vasoconstrictor Agents / pharmacology
Vasodilator Agents / pharmacology
Vasomotor System / drug effects
Reg. No./Substance:
0/Lipids; 0/Tobacco Smoke Pollution; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 486-56-6/Cotinine; 54-11-5/Nicotine

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