Document Detail


Nicotine delivery from smoking bidis and an additive-free cigarette.
MedLine Citation:
PMID:  12521408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was conducted to determine whether smoking bidis, an additive-free cigarette, and conventional cigarettes caused similar biochemical, physiological and subjective effects. This was an open-label, within-subject design. In each session, subjects (n = 10) smoked a single cigarette: an unfiltered Natural American Spirit, an unfiltered Irie bidi, an unfiltered Sher bidi, or one of the participant's own brand. The presentation of the cigarettes was randomized. Before and up to 1 h after smoking, biochemical markers [plasma nicotine levels and exhaled carbon monoxide (CO)] and physiological effects of nicotine (heart rate and blood pressure) were measured. After smoking, subjects completed two standardized tests of cigarette liking and cigarette sensations. American Spirit (32.1 ng/ml) and Irie bidi (26.0 ng/ml) cigarettes increased plasma nicotine more than the participant's own brand (18.5 ng/ml). Subjects smoked longer and took more puffs to consume the American Spirit (452.8 s, 14 puffs) and Sher bidi (354.4 s, 14 puffs) than the participant's own brand (297.4 s, 10 puffs). In spite of differences in nicotine delivery, participants rated all cigarettes as similar in nicotine content. Overall, the results indicate that bidis and the additive-free cigarette delivered nicotine, CO and (presumably) other toxic components of tobacco smoke in equal or greater amounts than conventional cigarettes. These results do not support an emerging belief that bidi cigarettes are safer than conventional brands.
Authors:
Jennifer L Malson; Eun M Lee; Eric T Moolchan; Wallace B Pickworth
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  4     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2003-01-10     Completed Date:  2003-04-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  485-90     Citation Subset:  IM    
Affiliation:
Intramural Research Program, National Institute on Drug Abuse, Baltimore, Maryland 21224, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Dioxide / metabolism
Female
Humans
Male
Nicotine / administration & dosage*,  analysis,  blood
Personal Satisfaction*
Plants, Toxic / chemistry*
Questionnaires
Smoking*
Tobacco / chemistry
Grant Support
ID/Acronym/Agency:
P50CA84718/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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