| Nicotine and coronary heart disease. | |
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MedLine Citation:
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PMID: 21239286 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Nicotine may contribute to accelerated atherogenesis by inducing hyperlipidemia, injuring endothelial cells, and/or promoting thrombosis, although the evidence is not conclusive. Nicotine is likely to contribute to acute ischemic events in people who already have coronary heart disease via adverse effects on systemic hemodynamics, by promoting thrombosis, constricting coronary arteries, and/or facilitating arrhythmogenesis. Pharmacodynamic studies suggest that nicotine inhaled in cigarette smoke may have different cardiovascular effects than that absorbed more slowly, as from nicotine gum or transdermally. The safety of chronic nicotine exposure, such as with medicinal use of nicotine, cannot be predicted and requires empiric evaluation. |
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Authors:
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N L Benowitz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Trends in cardiovascular medicine Volume: 1 ISSN: 1050-1738 ISO Abbreviation: Trends Cardiovasc. Med. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 2011-01-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9108337 Medline TA: Trends Cardiovasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 315-21 Citation Subset: - |
Copyright Information:
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Copyright © 1991. Published by Elsevier Inc. |
Affiliation:
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University of California-San Francisco, San Francisco General Hospital Medical Center, San Francisco, CA 94110, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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