Document Detail

Nicotine consumption and schizotypy in first-degree relatives of individuals with schizophrenia and non-psychiatric controls.
MedLine Citation:
PMID:  17897810     Owner:  NLM     Status:  MEDLINE    
Individuals with schizophrenia have very high rates of cigarette smoking, and much has been discovered about the influence of nicotine on brain functioning in schizophrenia. However, less is understood about the relationship between nicotine consumption and milder phenotypes related to schizophrenia, specifically schizotypy. This study examined the relationship between nicotine consumption and schizotypy in two unmedicated samples that included first-degree relatives and non-psychiatric controls. Forty-two first-degree relatives and 50 control participants were administered a self-report questionnaire on schizotypal features as well as a self-report questionnaire on smoking behavior. A positive relationship was found between smoking status and level of schizotypy, and higher levels of schizotypy significantly predicted the odds of being a smoker after controlling for gender and group status. Interestingly, group status was a significant moderator in the relationship between level of schizotypy and smoking status, such that the relationship between these two variables was only significant in the first-degree relatives. This is the first study to investigate the relationship between these variables in a sample of first-degree relatives of individuals with schizophrenia. Those individuals with more schizotypal features are presumably at greater risk for schizophrenia-spectrum disorders and thus may be more likely to smoke cigarettes given the known biochemical effects of nicotine on overt positive and negative symptoms of schizophrenia. Although relatives did not differ from controls in their level of self-reported schizotypy, the significant relationship between smoking status and schizotypy in the former group is likely explained by their genetic vulnerability to schizophrenia-spectrum disorders.
Michelle L Esterberg; Erin M Jones; Michael T Compton; Elaine F Walker
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-25
Journal Detail:
Title:  Schizophrenia research     Volume:  97     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2008-03-04     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  6-13     Citation Subset:  IM    
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MeSH Terms
Cross-Sectional Studies
Genetic Predisposition to Disease
Middle Aged
Risk Factors
Schizophrenia / diagnosis,  epidemiology,  genetics*
Schizotypal Personality Disorder / diagnosis,  epidemiology,  genetics*
Smoking / epidemiology,  genetics*
Southeastern United States
Statistics as Topic
Tobacco Use Disorder / diagnosis,  epidemiology,  genetics*
Grant Support
K23 MH067589/MH/NIMH NIH HHS; K23 MH067589-04/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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