Document Detail


Nicotine concentrations with concurrent use of cigarettes and nicotine replacement: a review.
MedLine Citation:
PMID:  12573169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper reviews the data on blood nicotine or saliva cotinine concentrations with concomitant smoking and use of nicotine replacement (NR) products. Eleven studies that provided data on blood nicotine concentrations, carbon monoxide in exhaled air, and number of cigarettes smoked were reviewed. At least one day had to be spent on concurrent use of cigarette and NR products. With simultaneous use of smoking and acute NR products (gum and inhaler) the nicotine concentrations were unchanged, whereas they increased (+54%) with nicotine patches. With both types of NR products, the number of cigarettes smoked per day was reduced by approximately 50% and carbon monoxide (CO) by 30%. Where smokers had the intention or received instructions to reduce smoking, a greater reduction in cigarettes smoked and exhaled CO was observed. Despite substantially increased nicotine concentrations (e.g., up to 3 times the approved dose) there were no significant adverse reactions. Concurrent use of NR products and cigarette smoking appears to be safe.
Authors:
Karl Olov Fagerström; John R Hughes
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  4 Suppl 2     ISSN:  1462-2203     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2002  
Date Detail:
Created Date:  2003-02-07     Completed Date:  2003-05-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  S73-9     Citation Subset:  IM    
Affiliation:
Fagerström Consulting AB and Smokers Information Center, Helsingborg, Sweden. karl.fagerstrom@swipnet.se
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MeSH Terms
Descriptor/Qualifier:
Humans
Nicotine / analogs & derivatives*,  blood
Smoking / prevention & control*
Smoking Cessation / methods*
Tobacco Use Disorder / prevention & control*
Grant Support
ID/Acronym/Agency:
DA00490/DA/NIDA NIH HHS; DA11557/DA/NIDA NIH HHS; DA11935/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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