Document Detail


Nicotine, cigarette smoking and cardiac arrhythmia: an overview.
MedLine Citation:
PMID:  22779085     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Tobacco smoke is the single most important modifiable risk factor for coronary diseases and the leading preventable cause of death in the US. While the effect of cigarette smoking on the progression of atherosclerotic diseases is established and well studied, the role of cigarette smoking on cardiac arrhythmia is less clearly defined. In fact the pathophysiological mechanism of cigarette smoking-induced cardiac arrhythmia is very likely a complex one where the pro-fibrotic effect of nicotine on myocardial tissue with consequent increased susceptibility to catecholamine might play a role. Moreover, other constituents of cigarette smoking, such as carbon monoxide and oxidative stress, are likely to contribute to the generation of arrhythmias. Finally, cigarette smoking may induce coronary artery disease and chronic obstructive pulmonary disease, which also might cause arrhythmia independently. The objective of this paper is to summarize the published studies relating to cardiac arrhythmia induced by cigarette smoking, and to identify a pathophysiological mechanism by which cigarette smoking might induce cardiac arrhythmia.
Authors:
Alessandra D'Alessandro; Irina Boeckelmann; Matthias Hammwhöner; Andreas Goette
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of preventive cardiology     Volume:  19     ISSN:  2047-4881     ISO Abbreviation:  Eur J Prev Cardiol     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-07-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101564430     Medline TA:  Eur J Prev Cardiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  297-305     Citation Subset:  IM    
Affiliation:
Section of Occupational Medicine,Otto von Guericke University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany. alessandra.dalessandro@med.ovgu.de
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