Document Detail

Nicotine and carbon monoxide intake from high- and low-yield cigarettes.
MedLine Citation:
PMID:  6744784     Owner:  NLM     Status:  MEDLINE    
We measured daily nicotine intake in 11 habitual smokers who smoked their usual brand or commercial high-yield (Federal Trade Commission [FTC] yield 1.2 mg nicotine, 16 mg tar) or low-yield (0.4 mg nicotine, 5 mg tar) cigarettes. Daily nicotine intake was measured from metabolic clearance data in conjunction with blood and urinary concentrations of nicotine during 24-hr smoking periods. On the average, subjects consumed 35 mg nicotine while smoking their usual cigarettes and 26 mg while smoking either high- or low-yield commercial cigarettes different from their usual brand. This level of nicotine consumption from low-yield cigarettes was because smokers obtained 60% more nicotine per cigarette than predicted by FTC yield and they smoked 25% more cigarettes a day. Although there was considerable variability in nicotine intake between subjects, there was a correlation within subjects between intake while smoking their usual brand and experimental cigarettes. Nicotine intake between the two commercial high- or low-yield cigarettes also correlated (r = 0.86). These findings are consistent with a minimal level of acceptable daily intake of nicotine for individuals that is related to usual intake. We suggest that our protocol provides a better quantitative estimate of the yield of different cigarette brands and potential health hazards than those currently provided by the FTC.
N L Benowitz; P Jacob
Related Documents :
18295884 - Impulsivity as a vulnerability marker for substance-use disorders: review of findings f...
19010884 - Smokers with the chrna lung cancer-associated variants are exposed to higher levels of ...
16011894 - Non-nicotine pharmacotherapies for smoking cessation.
2224914 - Theoretical and experimentally quantifiable determinants of tobacco smoking behavior fo...
12057864 - Pet birds and risk of lung cancer in north-western germany.
18973414 - Evaluation of cruzia americana, turgida turgida, and didelphostrongylus hayesi infectio...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  36     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-17     Completed Date:  1984-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Carbon Monoxide / administration & dosage*
Carboxyhemoglobin / analysis
Middle Aged
Nicotine / administration & dosage*,  blood
Plants, Toxic*
Sex Factors
Grant Support
Reg. No./Substance:
54-11-5/Nicotine; 630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effect of oral amrinone on platelet function and survival.
Next Document:  Circadian stage-dependent changes in diazepam kinetics.