Document Detail


Nicotine and carbon monoxide intake from high- and low-yield cigarettes.
MedLine Citation:
PMID:  6744784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured daily nicotine intake in 11 habitual smokers who smoked their usual brand or commercial high-yield (Federal Trade Commission [FTC] yield 1.2 mg nicotine, 16 mg tar) or low-yield (0.4 mg nicotine, 5 mg tar) cigarettes. Daily nicotine intake was measured from metabolic clearance data in conjunction with blood and urinary concentrations of nicotine during 24-hr smoking periods. On the average, subjects consumed 35 mg nicotine while smoking their usual cigarettes and 26 mg while smoking either high- or low-yield commercial cigarettes different from their usual brand. This level of nicotine consumption from low-yield cigarettes was because smokers obtained 60% more nicotine per cigarette than predicted by FTC yield and they smoked 25% more cigarettes a day. Although there was considerable variability in nicotine intake between subjects, there was a correlation within subjects between intake while smoking their usual brand and experimental cigarettes. Nicotine intake between the two commercial high- or low-yield cigarettes also correlated (r = 0.86). These findings are consistent with a minimal level of acceptable daily intake of nicotine for individuals that is related to usual intake. We suggest that our protocol provides a better quantitative estimate of the yield of different cigarette brands and potential health hazards than those currently provided by the FTC.
Authors:
N L Benowitz; P Jacob
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  36     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1984 Aug 
Date Detail:
Created Date:  1984-09-17     Completed Date:  1984-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Carbon Monoxide / administration & dosage*
Carboxyhemoglobin / analysis
Female
Humans
Male
Middle Aged
Nicotine / administration & dosage*,  blood
Plants, Toxic*
Sex Factors
Smoking*
Tobacco*
Grant Support
ID/Acronym/Agency:
CA32389/CA/NCI NIH HHS; DA01696/DA/NIDA NIH HHS; DA02277/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
54-11-5/Nicotine; 630-08-0/Carbon Monoxide; 9061-29-4/Carboxyhemoglobin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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