Document Detail

Nicotine attenuates the ventilatory response to hypoxia in the developing lamb.
MedLine Citation:
PMID:  7603786     Owner:  NLM     Status:  MEDLINE    
Decreased ability to generate a hyperventilatory response to hypoxemia is believed to be an important mechanism in the pathophysiology of sudden infant death syndrome, and maternal smoking is a leading risk factor. To investigate whether there may be a link between these two observations, we studied five lambs at mean ages of 7, 17, and 27 d to determine the effects of an i.v. infusion of nicotine (0.5 microgram/kg/min) on ventilation when peripheral chemoreceptor activity was stimulated by hypoxia (0.1 FiO2) or briefly inhibited by hyperoxia. Ventilatory measurements were performed using a computer-aided occlusion valve device which permitted breath-by-breath determinations of inspiratory occlusion pressures (P0.1) and minute ventilation. Nicotine attenuated the early ventilatory response to hypoxia (min 1, 2, and 3 of the test) by 8, 26, and 37%, respectively, at the age of 7 d (analysis of variance overall, p < 0.05), by 23%, 23 and 37% at 17 d (p = NS) and by 40, 45, and 37% at 27 d (p < 0.05). The decrease in ventilation in response to hyperoxia during the control study without nicotine was 18, 35, and 34% at 7, 17, and 27 d, respectively. Nicotine caused a greater decrease in the response: 31, 45, and 46%, respectively, (p < 0.05 at 27 d). The paradoxical effects of nicotine, attenuation of the ventilatory response to hypoxia and augmentation of the response to hyperoxia, suggest that nicotine altered peripheral chemoreceptor oxygen sensitivity and most likely also affected central processing of the chemoreceptor input.(ABSTRACT TRUNCATED AT 250 WORDS)
J Milerad; H Larsson; J Lin; H W Sundell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  37     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  652-60     Citation Subset:  IM    
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee 37232-2585, USA.
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MeSH Terms
Age Factors
Anoxia / physiopathology*
Electric Impedance
Hyperoxia / physiopathology*
Nicotine / pharmacology*
Respiration / drug effects*
Respiratory Function Tests
Grant Support
Reg. No./Substance:

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