| Nicotine administration and withdrawal affect survival in systemic inflammation models. | |
| | |
MedLine Citation:
|
PMID: 18617624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
How different regimens of nicotine administration and withdrawal affect systemic inflammation is largely unknown. We studied the effects of chronic and acute nicotine administration and of nicotine withdrawal on the outcome of aseptic and septic systemic inflammation. Male C57BL/6 mice were implanted with subcutaneous osmotic pumps (to deliver nicotine) and intrabrain telemetry probes (to measure temperature). Aseptic inflammation was induced by lipopolysaccharide (40 mg/kg ip); sepsis was induced by cecal ligation and puncture. The chronic nicotine administration group received nicotine (28 mg.kg(-1).day(-1)) for 2 wk before the induction of inflammation and continued receiving nicotine until the end of the experiment; the acute nicotine administration group received saline for 2 wk and nicotine thereafter; the nicotine withdrawal group received nicotine for 2 wk and saline thereafter; and the no-nicotine group was infused with saline throughout the experiment. Compared with no nicotine, the chronic nicotine administration did not affect survival in either model of inflammation, possibly due to the development of nicotine tolerance. The acute nicotine administration increased the survival rate in aseptic inflammation from 11 to 33% (possibly by suppressing inflammation) but worsened the outcome of sepsis (possibly because the suppression of inflammation promoted microbial proliferation). Oppositely to acute nicotine, nicotine withdrawal increased the survival rate in sepsis from 18 to 40%. The effects on survival were not due to changes in body temperature. We conclude that acute nicotine administration and nicotine withdrawal affect survival in systemic inflammation and that these effects strongly depend on whether inflammation is aseptic or septic. |
| | |
Authors:
|
Alexandre A Steiner; Daniela L Oliveira; Jennifer L Roberts; Scott R Petersen; Andrej A Romanovsky |
Related Documents
:
|
23127204 - Pharmacokinetics and safety profile of a novel progesterone aqueous formulation adminis... 23601084 - Peripheral selectivity of the novel cannabinoid receptor antagonist tm38837 in healthy ... 4096744 - Effects of ticlopidine on blood fibrinogen and blood viscosity in peripheral atheroscle... 9134584 - Pharmacokinetics and radiosensitizing effect of pr-350. 2970854 - Pharmacokinetics of single and consecutive doses of cilazapril and its depressor effect... 7749974 - Characterization of daytime sleepiness and psychomotor performance following h1 recepto... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-07-10 |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 105 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2008 Oct |
Date Detail:
|
Created Date: 2008-10-07 Completed Date: 2008-11-06 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1028-34 Citation Subset: IM |
Affiliation:
|
Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, 350 W. Thomas Rd., Phoenix, AZ 85013, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Temperature / drug effects Cecum / microbiology, surgery Disease Models, Animal Disease Progression Drug Administration Schedule Infusion Pumps, Implantable Lipopolysaccharides Male Mice Mice, Inbred C57BL Nicotine / administration & dosage* Nicotinic Agonists / administration & dosage* Sepsis / complications*, microbiology, physiopathology Substance Withdrawal Syndrome / complications*, physiopathology Systemic Inflammatory Response Syndrome / chemically induced, complications*, physiopathology Time Factors Tobacco Use Disorder / complications*, physiopathology |
| Grant Support | |
ID/Acronym/Agency:
|
R01 NS 41233/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Lipopolysaccharides; 0/Nicotinic Agonists; 54-11-5/Nicotine |
| Comments/Corrections | |
Comment In:
|
J Appl Physiol. 2008 Oct;105(4):1023-5
[PMID:
18719229
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Modulation of osteoclastogenesis by fatty acids.
Next Document: Human cerebral arteriovenous vasoactive exchange during alterations in arterial blood gases.