Document Detail

Nicotine administration and withdrawal affect survival in systemic inflammation models.
MedLine Citation:
PMID:  18617624     Owner:  NLM     Status:  MEDLINE    
How different regimens of nicotine administration and withdrawal affect systemic inflammation is largely unknown. We studied the effects of chronic and acute nicotine administration and of nicotine withdrawal on the outcome of aseptic and septic systemic inflammation. Male C57BL/6 mice were implanted with subcutaneous osmotic pumps (to deliver nicotine) and intrabrain telemetry probes (to measure temperature). Aseptic inflammation was induced by lipopolysaccharide (40 mg/kg ip); sepsis was induced by cecal ligation and puncture. The chronic nicotine administration group received nicotine (28 for 2 wk before the induction of inflammation and continued receiving nicotine until the end of the experiment; the acute nicotine administration group received saline for 2 wk and nicotine thereafter; the nicotine withdrawal group received nicotine for 2 wk and saline thereafter; and the no-nicotine group was infused with saline throughout the experiment. Compared with no nicotine, the chronic nicotine administration did not affect survival in either model of inflammation, possibly due to the development of nicotine tolerance. The acute nicotine administration increased the survival rate in aseptic inflammation from 11 to 33% (possibly by suppressing inflammation) but worsened the outcome of sepsis (possibly because the suppression of inflammation promoted microbial proliferation). Oppositely to acute nicotine, nicotine withdrawal increased the survival rate in sepsis from 18 to 40%. The effects on survival were not due to changes in body temperature. We conclude that acute nicotine administration and nicotine withdrawal affect survival in systemic inflammation and that these effects strongly depend on whether inflammation is aseptic or septic.
Alexandre A Steiner; Daniela L Oliveira; Jennifer L Roberts; Scott R Petersen; Andrej A Romanovsky
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-07-10
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  105     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-07     Completed Date:  2008-11-06     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1028-34     Citation Subset:  IM    
Systemic Inflammation Laboratory, Trauma Research, St. Joseph's Hospital and Medical Center, 350 W. Thomas Rd., Phoenix, AZ 85013, USA.
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MeSH Terms
Body Temperature / drug effects
Cecum / microbiology,  surgery
Disease Models, Animal
Disease Progression
Drug Administration Schedule
Infusion Pumps, Implantable
Mice, Inbred C57BL
Nicotine / administration & dosage*
Nicotinic Agonists / administration & dosage*
Sepsis / complications*,  microbiology,  physiopathology
Substance Withdrawal Syndrome / complications*,  physiopathology
Systemic Inflammatory Response Syndrome / chemically induced,  complications*,  physiopathology
Time Factors
Tobacco Use Disorder / complications*,  physiopathology
Grant Support
Reg. No./Substance:
0/Lipopolysaccharides; 0/Nicotinic Agonists; 54-11-5/Nicotine
Comment In:
J Appl Physiol (1985). 2008 Oct;105(4):1023-5   [PMID:  18719229 ]

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