| Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. | |
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MedLine Citation:
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PMID: 6236853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The distribution of cytosolic activity of nicotinamide:S-adenosylmethionine methyltransferase (nicotinamide methylase, EC 2.1.1.1) in normal tissues from adult rat and mouse and in tumors and the change in the enzyme activity during the development of rat tissues were studied. (1) Rat liver exhibited the highest nicotinamide methylase activity among all adult tissues tested; other rat tissues, like adrenal, pancreas, kidney, brain and mouse tissues, had only less than 15% of the adult rat liver activity. (2) 3 days before birth, fetal liver showed a very low nicotinamide methylase activity (2% of adult rat liver), which, however, increased already 1 day before birth and reached the adult level on the day 28 after birth. (3) In a variety of hepatomas and ascites tumors, an inverse correlation, with some exceptions, between tumor growth rate and nicotinamide methylase activity could be seen. In all hepatomas, with the exception of Morris hepatoma 5123tc, nicotinamide methylase activity was significantly decreased in comparison to normal adult rat liver. The highly malignant Zajdela hepatoma, Yoshida sarcoma, sarcoma 180 and Ehrlich ascites tumor methylated nicotinamide only at a negligibly low rate. (4) Cultured RLC cells (an established rat liver cell line) from the stationary growth phase or G1-arrested RLC cells had about half of the adult rat liver activity, yet the activity was 70% higher than that of the logarithmically growing RLC cells. |
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Authors:
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R Seifert; J Hoshino; H Kröger |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 801 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-11-13 Completed Date: 1984-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 259-64 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Brain / metabolism Carcinoma, Ehrlich Tumor / metabolism Cell Line Female Kidney / metabolism Liver / metabolism Liver Neoplasms, Experimental / metabolism Methylation Methyltransferases / metabolism* Mice Mice, Inbred Strains Neoplasms, Experimental / metabolism* Niacinamide / metabolism* Nicotinamide N-Methyltransferase Rats Rats, Inbred Strains Sarcoma 180 / metabolism* Sarcoma, Yoshida / metabolism Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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98-92-0/Niacinamide; EC 2.1.1.-/Methyltransferases; EC 2.1.1.1/Nicotinamide N-Methyltransferase; EC 2.1.1.1/Nnmt protein, mouse |
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