| Nicotinamide in dermatology and photoprotection. | |
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MedLine Citation:
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PMID: 22256624 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Nicotinamide (the amide form of vitamin B3) has been used in dermatology for more than 40 years for a diverse range of conditions including acne, rosacea, autoimmune bullous dermatoses, and now the treatment and prevention of photoaging and photoimmunosuppression. The broad clinical effects of nicotinamide may be explained by its role as a cellular energy precursor, a modulator of inflammatory cytokines, and an inhibitor of the nuclear enzyme poly(adenosine diphosphate-ribose) polymerase-1, which plays a significant role in DNA repair, maintenance ofgenomic stability, and cellular response to injury including inflammation and apoptosis. This review outlines the use of nicotinamide for inflammatory dermatoses and photoaging and focuses on its emerging role in photoprotection. |
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Authors:
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Devita Surjana; Diona L Damian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Skinmed Volume: 9 ISSN: 1540-9740 ISO Abbreviation: Skinmed Publication Date: 2011 Nov-Dec |
Date Detail:
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Created Date: 2012-01-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101168327 Medline TA: Skinmed Country: United States |
Other Details:
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Languages: eng Pagination: 360-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Sydney Cancer Centre, Bosch Institute, University of Sydney at Royal Prince Alfred Hospital, Camperdown, NSW, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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