| Nicorandil infusion leads to good recovery from ischemia of left ventricular regional work in comparison with nitroglycerin. | |
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MedLine Citation:
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PMID: 12381090 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nicorandil is an antianginal drug that exerts both a conventional nitrate effect and an independent ATP-dependent potassium channel-opening effect. The present study examined the effects of nicorandil on left ventricular regional work (RW) during coronary angioplasty in 22 patients with angina pectoris who were scheduled for angioplasty to the left anterior descending artery. The patients were randomly assigned to receive either nitroglycerin (group NG, n=12, 0.5 microg x kg(-1) min(-1)) or nicorandil (group NR, n = 10, 1.5 microg x kg(-1) min(-1)). Inflation was performed for 60 s and the data were collected every 10 s. The RW was derived from the relation between mean wall stress and area strain. The RW of the interventricular septum decreased after balloon inflation and was at its minimum after the 60s inflation (group NR: 1.24 +/- 0.72mJ/cm3, group NG: 0.63 +/- 0.25mJ/cm3). After balloon deflation, the septal RW of both groups increased, and recovered to the baseline condition at about 30s. At 20 s after deflation, the septal RW in group NR (3.58 +/- 1.17 mJ/cm3) was significantly higher than that in group NG (2.25 +/- 0.59mJ/cm3) (p < 0.05). An intravenous infusion of nicorandil led to good recovery of RW from ischemia compared with that obtained with nitroglycerin. |
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Authors:
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Naoki Isobe; Shigeru Oshima; Koichi Taniguchi; Hiroshi Hoshizaki; Hitoshi Adachi; Takuji Toyama; Shigeto Naito; Akihiko Nogami; Motoaki Sugawara |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 66 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-10-16 Completed Date: 2003-06-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 943-8 Citation Subset: IM |
Affiliation:
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Division of Cardiology, Gunma Prefectural Cardiovascular Center, Maebashi, Japan. isobe.n@cvc.pref.gunma.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / therapy Angioplasty, Transluminal, Percutaneous Coronary Anti-Arrhythmia Agents / administration & dosage*, pharmacology Electrocardiography Female Hemodynamics / drug effects Humans Male Middle Aged Myocardial Ischemia / drug therapy* Nicorandil / administration & dosage*, pharmacology Nitroglycerin / administration & dosage, pharmacology Treatment Outcome Ventricular Dysfunction, Left / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 55-63-0/Nitroglycerin; 65141-46-0/Nicorandil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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