| Nicorandil induces late preconditioning against myocardial infarction in conscious rabbits. | |
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MedLine Citation:
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PMID: 14684373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nicorandil has been shown to induce an infarct-limiting effect similar to that induced by the early phase of ischemic preconditioning (PC). The goals of this study were to determine whether nicorandil induces a delayed cardioprotection that is analogous to the late phase of ischemic PC and, if so, whether nicorandil-induced late PC is associated with upregulation of cardioprotective proteins. Chronically instrumented, conscious rabbits received vehicle (intravenous normal saline; control group, n = 10), nicorandil (100 microg/kg bolus + 30 microg x kg(-1) x min(-1) i.v. for 60 min; nicorandil group, n = 10), or ischemic PC (6 cycles of 4-min coronary occlusion/4-min reperfusion; PC group, n = 8). Twenty-four hours later, rabbits underwent a 30-min coronary occlusion, followed by 3 days of reperfusion. Myocardial infarct size was significantly reduced in rabbits pretreated with nicorandil (27.5 +/- 5.3% of the risk region) or with ischemia (30.3 +/- 4.2%) versus controls (59.1 +/- 4.7%, P < 0.05 vs. both). Furthermore, the expression of cyclooxygenase-2 (COX-2) and Bcl-2 was significantly elevated (+38% and +126%, respectively; P < 0.05) in myocardium of rabbits given nicorandil 24 h earlier versus controls. We conclude that nicorandil induces delayed cardioprotection against myocardial infarction similar to that afforded by the late phase of ischemic PC, possibly by upregulating COX-2 and Bcl-2. |
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Authors:
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Xian-Liang Tang; Yu-Ting Xuan; Yanqing Zhu; Gregg Shirk; Roberto Bolli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-12-18 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 286 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-03-15 Completed Date: 2004-04-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1273-80 Citation Subset: IM |
Affiliation:
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Institute of Moleculat Cardiology, University of Louisville, Louisville, KY 40292, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology* Blood Pressure / drug effects Blotting, Western Cyclooxygenase 2 Gene Expression / drug effects Genes, bcl-2 Heart Rate / drug effects Ischemic Preconditioning, Myocardial / methods* Isoenzymes / biosynthesis Male Myocardial Infarction / metabolism, pathology, prevention & control* Nicorandil / pharmacology* Prostaglandin-Endoperoxide Synthases / biosynthesis Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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HL-43151/HL/NHLBI NIH HHS; HL-55757/HL/NHLBI NIH HHS; HL-65660/HL/NHLBI NIH HHS; HL-68088/HL/NHLBI NIH HHS; HL-70897/HL/NHLBI NIH HHS; HL-74351/HL/NHLBI NIH HHS; HL-76794/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Isoenzymes; 65141-46-0/Nicorandil; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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