Document Detail


Nicorandil and cardiovascular performance in patients with coronary artery disease.
MedLine Citation:
PMID:  1282175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To establish the cardiovascular profile of nicorandil in patients with coronary artery disease, we recently conducted three studies at our institution. In two groups of patients undergoing cardiac catheterization, the effects of 20 mg nicorandil sublingually (s.l.) on, first, left ventricular hemodynamics (n = 10) and, second, coronary vasodilatation (n = 11) were investigated. In the first group, despite a significant decrease of 12% in left ventricular systolic pressure, heart rate did not increase significantly after nicorandil. Both left ventricular end-diastolic pressure (-43%) and the time constant of early isovolumic relaxation (-11%) decreased, whereas peak Vce and Vmax increased (+19%) (all significantly). In the second group, as mean aortic pressure decreased (-13%, p < 0.05), coronary sinus blood flow did not change significantly, and calculated coronary vascular resistance tended to decrease (-10%). Myocardial oxygen consumption decreased significantly by 14%. Quantitative coronary angiography confirmed a significant increase in the mean diameter of nonstenotic coronary artery segments (+ 14%, n = 43) and, importantly, in mean obstruction diameter of stenotic segments (+ 14%, n = 7) after s.l. nicorandil. In a third continuing study, the effects of intracoronary (i.c.) nicorandil (6 micrograms/kg) and isosorbide dinitrate (2 mg) on the epicardial coronary arteries were investigated in 10 patients undergoing coronary angioplasty. In nonstenotic coronary artery segments, mean coronary diameter increased significantly after either nicorandil (+ 12%) or isosorbide dinitrate (+ 17%). In stenotic segments, however, where the increase in obstruction diameter (+ 20%) after i.c. nicorandil was significant, the 8% increase of isosorbide dinitrate was not.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
H Suryapranata; D MacLeod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  20 Suppl 3     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1992  
Date Detail:
Created Date:  1993-02-01     Completed Date:  1993-02-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S45-51     Citation Subset:  IM    
Affiliation:
Cardiac Catheterization Laboratory, Thoraxcenter, Rotterdam, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Administration, Sublingual
Coronary Circulation / drug effects
Coronary Disease / drug therapy*,  physiopathology
Female
Hemodynamics / drug effects*
Humans
Isosorbide Dinitrate / pharmacology
Male
Middle Aged
Niacinamide / administration & dosage,  analogs & derivatives*,  pharmacology
Nicorandil
Vasodilation / drug effects
Vasodilator Agents / administration & dosage,  pharmacology*
Ventricular Function, Left / drug effects*
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 65141-46-0/Nicorandil; 87-33-2/Isosorbide Dinitrate; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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