| Nicorandil and cardiovascular performance in patients with coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 1282175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To establish the cardiovascular profile of nicorandil in patients with coronary artery disease, we recently conducted three studies at our institution. In two groups of patients undergoing cardiac catheterization, the effects of 20 mg nicorandil sublingually (s.l.) on, first, left ventricular hemodynamics (n = 10) and, second, coronary vasodilatation (n = 11) were investigated. In the first group, despite a significant decrease of 12% in left ventricular systolic pressure, heart rate did not increase significantly after nicorandil. Both left ventricular end-diastolic pressure (-43%) and the time constant of early isovolumic relaxation (-11%) decreased, whereas peak Vce and Vmax increased (+19%) (all significantly). In the second group, as mean aortic pressure decreased (-13%, p < 0.05), coronary sinus blood flow did not change significantly, and calculated coronary vascular resistance tended to decrease (-10%). Myocardial oxygen consumption decreased significantly by 14%. Quantitative coronary angiography confirmed a significant increase in the mean diameter of nonstenotic coronary artery segments (+ 14%, n = 43) and, importantly, in mean obstruction diameter of stenotic segments (+ 14%, n = 7) after s.l. nicorandil. In a third continuing study, the effects of intracoronary (i.c.) nicorandil (6 micrograms/kg) and isosorbide dinitrate (2 mg) on the epicardial coronary arteries were investigated in 10 patients undergoing coronary angioplasty. In nonstenotic coronary artery segments, mean coronary diameter increased significantly after either nicorandil (+ 12%) or isosorbide dinitrate (+ 17%). In stenotic segments, however, where the increase in obstruction diameter (+ 20%) after i.c. nicorandil was significant, the 8% increase of isosorbide dinitrate was not.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
H Suryapranata; D MacLeod |
Related Documents
:
|
1623875 - Paradoxical vasoconstriction as result of acetylcholine and serotonin in diseased human... 16707955 - Carotid intima-media thickness in coronary slow flow: relationship with plasma homocyst... 2881635 - Long-term nitroglycerin treatment: effect on direct and endothelium-mediated large coro... 21765125 - Effects of continuous-flow versus pulsatile-flow left ventricular assist devices on myo... 10595955 - Myocardial oxygen consumption is unchanged but efficiency is reduced in patients with e... 17302965 - Inhibition of vascular remodelling in a porcine coronary injury model by herbal extract... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of cardiovascular pharmacology Volume: 20 Suppl 3 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1992 |
Date Detail:
|
Created Date: 1993-02-01 Completed Date: 1993-02-01 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: S45-51 Citation Subset: IM |
Affiliation:
|
Cardiac Catheterization Laboratory, Thoraxcenter, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Sublingual Coronary Circulation / drug effects Coronary Disease / drug therapy*, physiopathology Female Hemodynamics / drug effects* Humans Isosorbide Dinitrate / pharmacology Male Middle Aged Niacinamide / administration & dosage, analogs & derivatives*, pharmacology Nicorandil Vasodilation / drug effects Vasodilator Agents / administration & dosage, pharmacology* Ventricular Function, Left / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Vasodilator Agents; 65141-46-0/Nicorandil; 87-33-2/Isosorbide Dinitrate; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pharmacokinetic profile of nicorandil in humans: an overview.
Next Document: Acute hemodynamic effects of nicorandil in coronary artery disease.