Document Detail

Nicorandil attenuates reperfusion injury after long cardioplegic arrest.
MedLine Citation:
PMID:  17540988     Owner:  NLM     Status:  MEDLINE    
The cardioprotective efficacy of nicorandil in cardiac surgery was determined using a surgically relevant 4-hr cardioplegic arrest model. Each isolated rabbit heart was parabiotically blood-perfused using a modified Langendorff column. The magnitude of left ventricular developed pressure and rate of change of developed pressure over time were measured before (baseline) and after ischemia. Nicorandil was administered either pre-ischemia, post-ischemia, pre/post-ischemia, or continuously (before, during, and after ischemia). The endothelium of the coronary artery was observed by scanning electron microscopy. Serum myeloperoxidase activities were also measured. Although pretreatment with nicorandil did not affect recovery of developed pressure, administration of nicorandil after ischemia, or before and after ischemia, enhanced the recovery of developed pressure. Serum myeloperoxidase activity was decreased in the pre/post-ischemia and continuous groups. Endothelial reperfusion injury decreased in all nicorandil-treated groups. Administration of nicorandil attenuated ischemia-reperfusion injury of the myocardium and coronary endothelium while ameliorating leukocyte activation. In the event of unexpected prolonged cardioplegic arrest, administration of nicorandil, even just after declamping, may improve cardiac function. However, pre-ischemia administration alone was not helpful in the heart subjected to prolonged cardioplegic arrest.
Kyoumi Takarabe; Yukio Okazaki; Shinya Higuchi; Junichi Murayama; Masafumi Natsuaki; Tsuyoshi Itoh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Asian cardiovascular & thoracic annals     Volume:  15     ISSN:  1816-5370     ISO Abbreviation:  Asian Cardiovasc Thorac Ann     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-01     Completed Date:  2008-04-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503417     Medline TA:  Asian Cardiovasc Thorac Ann     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
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MeSH Terms
Cardiotonic Agents / pharmacology*,  therapeutic use
Coronary Vessels / drug effects,  pathology
Disease Models, Animal
Endothelium, Vascular / drug effects,  pathology
Extracorporeal Circulation
Heart Arrest, Induced / adverse effects*
Leukocytes / drug effects,  enzymology
Myocardial Contraction / drug effects
Myocardial Reperfusion Injury / etiology,  physiopathology,  prevention & control,  therapy*
Nicorandil / pharmacology*,  therapeutic use
Peroxidase / blood
Time Factors
Ventricular Function, Left / drug effects
Ventricular Pressure / drug effects
Reg. No./Substance:
0/Cardiotonic Agents; 65141-46-0/Nicorandil; EC

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