Document Detail

Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death.
MedLine Citation:
PMID:  21871175     Owner:  NLM     Status:  In-Data-Review    
Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death. [BMB reports 2011; 44(8): 517-522].
So Jung Park; Ji Hyun Shin; Hee Kang; Jung Jin Hwang; Dong-Hyung Cho
Related Documents :
2985365 - The influence of temperature on the functions of cultured sertoli cells.
20508065 - Comparative analysis of the germ cell markers c-kit, ssea-1 and vasa in testicular biop...
12746325 - Pituitary hormones inhibit the function and differentiation of fetal sertoli cells.
17486275 - Immunolocalization assessment of metastasis-associated protein 1 in human and mouse mat...
22645115 - Endodermal cell-cell contact is required for the spatial control of casparian band deve...
11527575 - A stochastic, molecular model of the fission yeast cell cycle: role of the nucleocytopl...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BMB reports     Volume:  44     ISSN:  1976-670X     ISO Abbreviation:  BMB Rep     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465334     Medline TA:  BMB Rep     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Establishment and characterization of an immortalized human dermal papilla cell line.
Next Document:  Downregulation of ARFGEF1 and CAMK2B by promoter hypermethylation in breast cancer cells.