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Niclosamide induces mitochondria fragmentation and promotes both apoptotic and autophagic cell death.
MedLine Citation:
PMID:  21871175     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death. [BMB reports 2011; 44(8): 517-522].
Authors:
So Jung Park; Ji Hyun Shin; Hee Kang; Jung Jin Hwang; Dong-Hyung Cho
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BMB reports     Volume:  44     ISSN:  1976-670X     ISO Abbreviation:  BMB Rep     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101465334     Medline TA:  BMB Rep     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  517-22     Citation Subset:  IM    
Affiliation:
Graduate School of East-West Medical Science, Kyung Hee University, Yongin 446-701, Korea dhcho@khu.ac.kr.
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