| Nickel and molybdenum contact allergies in patients with coronary in-stent restenosis. | |
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MedLine Citation:
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PMID: 11130387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coronary in-stent restenosis might be triggered by contact allergy to nickel, chromate, or molybdenum ions released from stainless-steel stents. We investigated the association between allergic reactions to stent components and the occurrence of in-stent restenosis. METHODS: Patients with coronary stainless-steel stents who underwent angiography for suspected restenosis were consecutively included in this study. Quantitative coronary angiography for analysis of percentage diameter stenosis was done on 131 patients (mean age 62 years [SD 9]) with 171 stents 6.1 months (2.7) after stent implantation. All patients underwent epicutaneous patch tests (Finn chamber method) for nickel, chromate, molybdenum, manganese, and small 316L stainless-steel plates. Patch tests were assessed by independent dermatologists after 48 h, 72 h, and when necessary 96 h of contact with the potential allergen. FINDINGS: In-stent restenosis (> or =550% diameter stenosis) occurred in 89 patients. All ten patients with positive patch-test results had restenoses (p=0.03). Four male patients had positive reactions to molybdenum, and seven patients (four male, three female) had reactions to nickel. No patient with an allergic reaction to the standard test substances had a positive reaction to the stainless-steel plates. All patients with positive results had recurrent angina pectoris and needed target-vessel revascularisation. INTERPRETATION: Patients with allergic patch-test reactions to nickel and molybdenum had a higher frequency of in-stent restenoses than patients without hypersensitivity. Allergic reactions to nickel and molybdenum released from stents may be one of the triggering mechanisms for in-stent restenosis. |
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Authors:
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R Köster; D Vieluf; M Kiehn; M Sommerauer; J Kähler; S Baldus; T Meinertz; C W Hamm |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Lancet Volume: 356 ISSN: 0140-6736 ISO Abbreviation: Lancet Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-20 Completed Date: 2001-01-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985213R Medline TA: Lancet Country: England |
Other Details:
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Languages: eng Pagination: 1895-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Cardiology, University Hospital Eppendorf, Medical Clinic, Hamburg, Germany. rkoester@uke.uni-hamburg.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angioplasty, Transluminal, Percutaneous Coronary Coronary Angiography Coronary Disease / therapy* Dermatitis, Allergic Contact / diagnosis, etiology* Female Follow-Up Studies Humans Male Middle Aged Molybdenum / adverse effects*, diagnostic use Nickel / adverse effects*, diagnostic use Patch Tests Stents* |
| Chemical | |
Reg. No./Substance:
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7439-98-7/Molybdenum; 7440-02-0/Nickel |
| Comments/Corrections | |
Comment In:
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Lancet. 2001 Apr 14;357(9263):1206; author reply 1206-7
[PMID:
11332433
]
Lancet. 2001 Apr 14;357(9263):1205-6; author reply 1206-7 [PMID: 11332431 ] Lancet. 2001 Apr 14;357(9263):1206-7; author reply 1206-7 [PMID: 11332432 ] |
Erratum In:
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Lancet 2001 Jan 27;357(9252):316 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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