| Nickel induces oscillatory behavior and enhanced synaptic and electrotonic transmission between stomatogastric neurons of Panulirus interruptus. | |
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MedLine Citation:
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PMID: 8402148 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pyloric pattern generator network of the stomatogastric ganglion uses a mixture of burst-inducing plateau potentials, synaptic transmission, and electrical coupling to produce its patterned output. This study examines the effects of two divalent, calcium channel blockers, nickel and cadmium, on voltage oscillations, synaptic transmission, and electrical coupling between the two pyloric dilator (PD) neurons and lateral pyloric (LP) neuron of Panulirus interruptus. The in vitro stomatogastric ganglion was bathed in saline containing tetrodotoxin (TTX) to eliminate Na-spikes and the spontaneous voltage oscillations of the pyloric rhythm, resulting in a steady resting potential. Addition of 50-100 microM Ni2+ to the TTX-saline induced voltage oscillations of similar amplitude and frequency as the endogenous rhythmic activity (before the application of TTX). 25-50 microM nickel enhanced graded synaptic transmission and electrical coupling and altered voltage waveforms, while producing little change in the input resistance measured in the soma. 10-1000 microM Cd2+ acted as a dose-dependent blocker of graded synaptic transmission, but had no other detectable effects. We propose that nickel, in contrast to cadmium, exerts a modulator-like effect deep in the pyloric neuropil. |
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Authors:
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L Zirpel; D Baldwin; K Graubard |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 617 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1993 Jul |
Date Detail:
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Created Date: 1993-10-29 Completed Date: 1993-10-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 205-13 Citation Subset: IM |
Affiliation:
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Department of Physiology and Biophysics, University of Washington, Seattle 98195. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channel Blockers / pharmacology* Ganglia, Invertebrate / drug effects*, physiology Membrane Potentials / drug effects Nephropidae / drug effects* Neurons / drug effects*, physiology Nickel / pharmacology* Oscillometry Pyloric Antrum / innervation Synapses / drug effects Synaptic Transmission / drug effects* Tetrodotoxin / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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GM07108/GM/NIGMS NIH HHS; NS15697/NS/NINDS NIH HHS; NS25505/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channel Blockers; 4368-28-9/Tetrodotoxin; 7440-02-0/Nickel |
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