Document Detail


Nickel induces oscillatory behavior and enhanced synaptic and electrotonic transmission between stomatogastric neurons of Panulirus interruptus.
MedLine Citation:
PMID:  8402148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pyloric pattern generator network of the stomatogastric ganglion uses a mixture of burst-inducing plateau potentials, synaptic transmission, and electrical coupling to produce its patterned output. This study examines the effects of two divalent, calcium channel blockers, nickel and cadmium, on voltage oscillations, synaptic transmission, and electrical coupling between the two pyloric dilator (PD) neurons and lateral pyloric (LP) neuron of Panulirus interruptus. The in vitro stomatogastric ganglion was bathed in saline containing tetrodotoxin (TTX) to eliminate Na-spikes and the spontaneous voltage oscillations of the pyloric rhythm, resulting in a steady resting potential. Addition of 50-100 microM Ni2+ to the TTX-saline induced voltage oscillations of similar amplitude and frequency as the endogenous rhythmic activity (before the application of TTX). 25-50 microM nickel enhanced graded synaptic transmission and electrical coupling and altered voltage waveforms, while producing little change in the input resistance measured in the soma. 10-1000 microM Cd2+ acted as a dose-dependent blocker of graded synaptic transmission, but had no other detectable effects. We propose that nickel, in contrast to cadmium, exerts a modulator-like effect deep in the pyloric neuropil.
Authors:
L Zirpel; D Baldwin; K Graubard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  617     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1993 Jul 
Date Detail:
Created Date:  1993-10-29     Completed Date:  1993-10-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Washington, Seattle 98195.
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MeSH Terms
Descriptor/Qualifier:
Animals
Calcium Channel Blockers / pharmacology*
Ganglia, Invertebrate / drug effects*,  physiology
Membrane Potentials / drug effects
Nephropidae / drug effects*
Neurons / drug effects*,  physiology
Nickel / pharmacology*
Oscillometry
Pyloric Antrum / innervation
Synapses / drug effects
Synaptic Transmission / drug effects*
Tetrodotoxin / pharmacology
Grant Support
ID/Acronym/Agency:
GM07108/GM/NIGMS NIH HHS; NS15697/NS/NINDS NIH HHS; NS25505/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 4368-28-9/Tetrodotoxin; 7440-02-0/Nickel

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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