Document Detail

Nickel earlobe dermatitis and clinical non-relevance of the oral exposure.
MedLine Citation:
PMID:  18498338     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Nickel is the most common cause of allergic contact dermatitis (ACD). Because nickel restriction is commonly imposed on many patients with the only earlobe ACD to nickel hypersensitivity, the aim of this study was to identify the role of occasional and extended oral nickel exposure in these patients. DESIGN: This is a case-control study. SUBJECTS: Thirty-four outpatients, previously diagnosed as monosensitized to nickel, suffering from earlobe dermatitis were enrolled; 11 of them showed active dermatitis. The control group consisted of six healthy (non-nickel-sensitive) subjects. INTERVENTIONS: High oral nickel challenge (20 mg) and protracted oral challenge (1 mg once a day). Observation period: 6 weeks. RESULTS: Clinical earlobe lesions were not affected by a high oral nickel intake nor by a protracted oral challenge. CONCLUSIONS: Dietary nickel restriction seems to be useless in patients with earlobe ACD due to nickel hypersensitivity.
F Di Berardino; D Alpini; A Cesarani
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Publication Detail:
Type:  Journal Article     Date:  2008-05-21
Journal Detail:
Title:  Journal of the European Academy of Dermatology and Venereology : JEADV     Volume:  22     ISSN:  1468-3083     ISO Abbreviation:  J Eur Acad Dermatol Venereol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9216037     Medline TA:  J Eur Acad Dermatol Venereol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1215-7     Citation Subset:  IM    
Audiology Unit, I.R.C.C.S., Policlinico, Mangiagalli e Regina Elena, Department of Otolaryngology, Chair of Audiology and Phoniatrics, University of Milan, Milano, Italy.
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MeSH Terms
Administration, Oral
Case-Control Studies
Dermatitis, Allergic Contact / etiology*
Ear / pathology*
Nickel / administration & dosage,  adverse effects*
Reg. No./Substance:

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