Document Detail

Nickel-catalyzed C-H alkenylation and alkylation of 1,3,4-oxadiazoles with alkynes and styrenes.
MedLine Citation:
PMID:  20560577     Owner:  NLM     Status:  MEDLINE    
The addition reaction of 1,3,4-oxadiazoles to alkynes via C-H bond cleavage efficiently proceeds in the presence of a nickel catalyst. This direct coupling allows a facile access to alkenyl-substituted oxadiazoles. The reaction with styrenes in place of alkynes is also available to selectively afford the corresponding branched adducts.
Tomoya Mukai; Koji Hirano; Tetsuya Satoh; Masahiro Miura
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  74     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6410-3     Citation Subset:  IM    
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Alkynes / chemistry*
Carbon / chemistry*
Hydrogen / chemistry*
Nickel / chemistry*
Oxadiazoles / chemistry*
Selenium / chemistry
Styrene / chemistry*
Reg. No./Substance:
0/Alkynes; 0/Oxadiazoles; 100-42-5/Styrene; 1333-74-0/Hydrogen; 7440-02-0/Nickel; 7440-44-0/Carbon; 7782-49-2/Selenium

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