| Nickel (Ni) allergic patients with complications to Ni containing joint replacement show preferential IL-17 type reactivity to Ni. | |
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MedLine Citation:
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PMID: 20597929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Some nickel (Ni) allergic patients develop complications following Ni-containing arthroplasty. In the peri-implant tissue of such patients, we had observed lymphocyte dominated inflammation together with IFN-gamma and IL-17 expression. OBJECTIVES: To determine whether Ni stimulation of peripheral blood mononuclear cells (PBMCs) of such patients would lead to a different cytokine pattern as compared to Ni-allergic patients with symptom-free arthroplasty. PATIENTS AND METHODS: Based on history and patch testing in 15 Ni-allergic patients (five without implant, five with symptom-free arthroplasty, five with complicated arthroplasty) and five non-allergic individuals, lymphocyte transformation test (LTT) was performed using PBMC. In parallel in vitro cytokine response to Ni was assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: All 15 Ni-allergic individuals showed enhanced LTT reactivity to Ni (mean SI = 8.42 +/- 1.8) compared to the non-allergic control group. Predominant IFN-gamma expression to Ni was found both in the five allergic patients without arthroplasty and also in the five allergic, symptom-free arthroplasty patients. In contrast, in the five Ni-allergic patients with arthroplasty-linked complications a predominant, significant IL-17 expression to Ni was seen but not in patients with symptom-free arthroplasty. CONCLUSIONS: The predominant IL-17 type response to Ni may characterize a subgroup of Ni-allergic patients prone to develop lymphocytic peri-implant hyper-reactivity. |
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Authors:
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Burkhard Summer; Carina Paul; Farhad Mazoochian; Christoph Rau; Marc Thomsen; Ingo Banke; Hans Gollwitzer; Karin-Almut Dietrich; Susanne Mayer-Wagner; Thomas Ruzicka; Peter Thomas |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Contact dermatitis Volume: 63 ISSN: 1600-0536 ISO Abbreviation: Contact Derm. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-05 Completed Date: 2010-10-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7604950 Medline TA: Contact Dermatitis Country: Denmark |
Other Details:
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Languages: eng Pagination: 15-22 Citation Subset: IM |
Affiliation:
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Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München, Germany. Burkhard.Summer@med.uni-muenchen.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Arthroplasty, Replacement / adverse effects* Case-Control Studies Dermatitis, Allergic Contact / etiology, immunology* Female Humans Interferon-gamma / blood, immunology Interleukin-17 / blood, immunology* Joint Prosthesis / adverse effects* Leukocytes, Mononuclear / immunology Lymphocyte Activation / immunology Male Middle Aged Nickel / immunology* Reverse Transcriptase Polymerase Chain Reaction Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-17; 7440-02-0/Nickel; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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