Document Detail

Nickel (Ni) allergic patients with complications to Ni containing joint replacement show preferential IL-17 type reactivity to Ni.
MedLine Citation:
PMID:  20597929     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Some nickel (Ni) allergic patients develop complications following Ni-containing arthroplasty. In the peri-implant tissue of such patients, we had observed lymphocyte dominated inflammation together with IFN-gamma and IL-17 expression. OBJECTIVES: To determine whether Ni stimulation of peripheral blood mononuclear cells (PBMCs) of such patients would lead to a different cytokine pattern as compared to Ni-allergic patients with symptom-free arthroplasty. PATIENTS AND METHODS: Based on history and patch testing in 15 Ni-allergic patients (five without implant, five with symptom-free arthroplasty, five with complicated arthroplasty) and five non-allergic individuals, lymphocyte transformation test (LTT) was performed using PBMC. In parallel in vitro cytokine response to Ni was assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: All 15 Ni-allergic individuals showed enhanced LTT reactivity to Ni (mean SI = 8.42 +/- 1.8) compared to the non-allergic control group. Predominant IFN-gamma expression to Ni was found both in the five allergic patients without arthroplasty and also in the five allergic, symptom-free arthroplasty patients. In contrast, in the five Ni-allergic patients with arthroplasty-linked complications a predominant, significant IL-17 expression to Ni was seen but not in patients with symptom-free arthroplasty. CONCLUSIONS: The predominant IL-17 type response to Ni may characterize a subgroup of Ni-allergic patients prone to develop lymphocytic peri-implant hyper-reactivity.
Burkhard Summer; Carina Paul; Farhad Mazoochian; Christoph Rau; Marc Thomsen; Ingo Banke; Hans Gollwitzer; Karin-Almut Dietrich; Susanne Mayer-Wagner; Thomas Ruzicka; Peter Thomas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  63     ISSN:  1600-0536     ISO Abbreviation:  Contact Derm.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-05     Completed Date:  2010-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  15-22     Citation Subset:  IM    
Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität, München, Germany.
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MeSH Terms
Aged, 80 and over
Arthroplasty, Replacement / adverse effects*
Case-Control Studies
Dermatitis, Allergic Contact / etiology,  immunology*
Interferon-gamma / blood,  immunology
Interleukin-17 / blood,  immunology*
Joint Prosthesis / adverse effects*
Leukocytes, Mononuclear / immunology
Lymphocyte Activation / immunology
Middle Aged
Nickel / immunology*
Reverse Transcriptase Polymerase Chain Reaction
Young Adult
Reg. No./Substance:
0/Interleukin-17; 7440-02-0/Nickel; 82115-62-6/Interferon-gamma

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