| Nickel-catalyzed arylative ring-opening of 3-methylenecycloalkane-1,1-dicarboxylates. | |
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MedLine Citation:
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PMID: 20394417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An arylative ring-opening reaction of cyclic allylmalonates with arylzinc reagents under nickel catalysis has been developed. Upon the ring-opening sp(3)C-sp(3)C bond cleavage, the allylic moiety serves as an allylic electrophile to react with arylzinc reagents. Simultaneously, the malonate moiety is converted to the corresponding zinc enolate, which can react further with electrophiles. The overall process increases molecular complexity and diversity starting from readily available substrates and is useful in organic synthesis. |
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Authors:
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Yuto Sumida; Hideki Yorimitsu; Koichiro Oshima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Organic letters Volume: 12 ISSN: 1523-7052 ISO Abbreviation: Org. Lett. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890393 Medline TA: Org Lett Country: United States |
Other Details:
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Languages: eng Pagination: 2254-7 Citation Subset: IM |
Affiliation:
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Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Catalysis Dicarboxylic Acids / chemical synthesis*, chemistry* Molecular Structure Nickel / chemistry* Organometallic Compounds / chemistry* Stereoisomerism Zinc / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Dicarboxylic Acids; 0/Organometallic Compounds; 7440-02-0/Nickel; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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