Document Detail

Nicardipine versus metoprolol in the treatment of hypertension during pregnancy: a randomized comparative trial.
MedLine Citation:
PMID:  8058230     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the effects of treatment with nicardipine and metoprolol in patients with hypertension during pregnancy. METHODS: One hundred pregnant patients with mild or moderate hypertension followed at the Centre Hospitalier Intercommunal de Créteil (France) were randomly allocated to treatment with either nicardipine or metoprolol. Changes in maternal blood pressure (BP), laboratory indices, umbilical Doppler velocimetry, and neonatal outcome were compared by means of Student t test, chi 2 test, and analysis of variance. RESULTS: Nicardipine decreased maternal systolic and diastolic BP more than metoprolol (P < .001). Umbilical artery resistance was lower in nicardipine-treated patients (P < .001). Plasma uric acid and creatinine concentrations were increased less markedly in the nicardipine group (P < .05 and P < .01, respectively). The incidence of cesarean delivery for fetal distress was lower in the nicardipine group (P < .01). There was a trend toward higher birth weights in the nicardipine group but no significant difference in neonatal outcome. CONCLUSION: Nicardipine is more effective than metoprolol in decreasing maternal BP; neonatal outcome is not significantly different.
D Jannet; B Carbonne; E Sebban; J Milliez
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  84     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-09     Completed Date:  1994-09-09     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  354-9     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Hôpital Saint-Antoine, Paris, France.
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MeSH Terms
Birth Weight
Blood Pressure / drug effects
Cesarean Section / statistics & numerical data
Drug Administration Schedule
Hypertension / drug therapy*
Infant, Newborn
Metoprolol / therapeutic use*
Nicardipine / therapeutic use*
Pre-Eclampsia / drug therapy*
Pregnancy Complications, Cardiovascular / drug therapy*
Pregnancy Outcome
Reg. No./Substance:
37350-58-6/Metoprolol; 55985-32-5/Nicardipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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