Document Detail

Nicardipine hydrochloride injectable phase IV open-label clinical trial: study on the anti-hypertensive effect and safety of nicardipine for acute aortic dissection.
MedLine Citation:
PMID:  12166354     Owner:  NLM     Status:  MEDLINE    
We performed a multicentre, phase IV, open-label clinical trial to examine the clinical usefulness of a continuous infusion of nicardipine hydrochloride to control hypertension in 31 patients with acute aortic dissection. Target blood pressure levels were reached within 15 min in 16 patients; in 15-30 min in 10 patients; in 30-45 min in three patients; and in 45-60 min in two patients. Baseline average systolic, diastolic and mean arterial blood pressures were 147 +/- 23 mmHg, 82 +/- 18 mmHg and 104 +/- 18 mmHg, respectively, with third-day pressures significantly reduced at 119 +/- 12 mmHg, 69 +/- 9 mmHg and 86 +/- 8 mmHg. Blood pressures after discontinuation of the infusion were not significantly different from those measured on the third day of infusion and no definite adverse effects attributable to the treatment were observed. Nicardipine hydrochloride was both effective and safe at controlling blood pressure in patients with acute aortic dissection.
K H Kim; I S Moon; J S Park; Y B Koh; H Ahn
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Publication Detail:
Type:  Clinical Trial; Clinical Trial, Phase IV; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  30     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-08-08     Completed Date:  2003-01-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  337-45     Citation Subset:  IM    
Department of Thoracic and Cardiovascular Surgery, Clinical Research Institute, College of Medicine Seoul National University, Seoul National University Hospital, Seoul, Korea.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  adverse effects,  therapeutic use*
Aortic Rupture / drug therapy*,  physiopathology
Blood Pressure
Nicardipine / administration & dosage,  adverse effects,  therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Antihypertensive Agents; 55985-32-5/Nicardipine

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