| Nicardipine infusion for blood pressure control in patients with subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 20535586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: To evaluate the efficacy, tolerability, and safety of nicardipine infusion in controlling the elevated blood pressure after subarachnoid hemorrhage (SAH). METHODS: Nicardipine infusion was initiated if the individual pre-specified systolic blood pressure (SBP) level goal, mandated by the admitting neurosurgeon, was not met. Systolic and diastolic BPs were measured on admission, hourly during the infusion and 12 h before and after the infusion. RESULTS: Twenty-eight patients with SAH required 50 nicardipine infusions in order to achieve a mean SBP goal of 152 mmHg. The 3,112 extracted BP measurements showed that mean infusion SBP was significantly lower than admission and pre-infusion SBP (mean 146.5 vs. 177.1 and 155.6 mmHg, P < 0.001, respectively) and significantly higher than post-infusion SBP (146.5 vs. 142.6 mmHg, P = 0.002). Five infusions were stopped prematurely, because of hypotension (n = 3), emergent surgery (n = 1), and failure to reach the SBP goal (n = 1). Rebleeding was not observed in any patient. Nicardipine achieved SBP control in 59.9% of hourly infusion measurements, with a trend for higher proportion of success with higher SBP goals. CONCLUSION: In this study, nicardipine infusion was a safe and moderately effective treatment for BP control in patients with SAH. Although SBP during nicardipine infusion was higher than the pre-specified goal in a significant percentage of hourly observations, this may be due to the drug administration protocol and other factors such as analgesia and sedation. |
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Authors:
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Panayiotis N Varelas; Tamer Abdelhak; Jody Wellwood; Irem Shah; Lotfi Hacein-Bey; Lonni Schultz; Panayiotis Mitsias |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurocritical care Volume: 13 ISSN: 1556-0961 ISO Abbreviation: Neurocrit Care Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2011-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101156086 Medline TA: Neurocrit Care Country: United States |
Other Details:
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Languages: eng Pagination: 190-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, K-11, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA. varelas@neuro.hfh.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / administration & dosage, therapeutic use Blood Pressure / drug effects* Diastole / drug effects Female Glasgow Coma Scale Homeostasis Humans Infusions, Intravenous Intracranial Aneurysm / drug therapy Male Middle Aged Nicardipine / administration & dosage, therapeutic use Subarachnoid Hemorrhage / drug therapy* Systole / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 55985-32-5/Nicardipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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