Document Detail


Nicaragua revisited: evidence of lower prevalence of chronic kidney disease in a high-altitude, coffee-growing village.
MedLine Citation:
PMID:  21956767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic kidney disease (CKD) is found at epidemic levels in certain populations of the Pacific Coast in northwestern Nicaragua especially in younger men. There are knowledge gaps concerning CKD's prevalence in regions at higher altitudes.
METHODS: A cross-sectional study of adults between the ages of 20 and 60 years in 1 coffee-growing village in Nicaragua located at 1,000 m above sea level (MASL) altitude was performed. Predictors included participant sex, age, occupation, conventional CKD risk factors and other factors associated with CKD suggested by previous surveys in Central America. Outcomes included serum creatinine (SCr) values >1.2 mg/dL for men and >0.9 mg/dL for women, estimated glomerular filtration rate (GFR) <60 ml/min per 1.73 m2, dipstick proteinuria stratified as microalbuminuria (30-300 mg/dL) and macroalbuminuria (>300 mg/dL), hypertension and body mass index.
RESULTS: Of 324 eligible participants, 293 were interviewed (90.4%), and 267 of those received the physical exam (82.4% overall). Of the sample, 45% were men. Prevalence rate of estimated GFR <60 ml/min per 1.73 m2 was 0 for men (0%) and 2 for women (1.4%). The prevalence of at least microalbuminuria was significantly higher among men compared with women (27.5% vs. 21.4%, respectively; p=0.02).
CONCLUSIONS: The CKD prevalence in this village is comparable to a previously studied Nicaraguan coffee-farming region and much lower than previously screened portions of northwestern Nicaragua. There is heterogeneity in CKD prevalence across Nicaragua. At this time, screenings should target individuals living in previously identified, higher risk regions. More work is needed to understand determinants of CKD in this resource-poor nation.
Authors:
Timothy S Laux; Philip J Bert; Gerardo M Barreto Ruiz; Marvin González; Mark Unruh; Aurora Aragon; Cecilia Torres Lacourt
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nephrology     Volume:  25     ISSN:  1724-6059     ISO Abbreviation:  J. Nephrol.     Publication Date:    2012 Jul-Aug
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-11-13     Revised Date:  2013-04-23    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  533-40     Citation Subset:  IM    
Affiliation:
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. TL1174@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Agriculture*
Albuminuria / epidemiology
Altitude*
Biological Markers / blood
Chi-Square Distribution
Chronic Disease
Coffea
Comorbidity
Creatinine / blood
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Health Surveys
Humans
Kidney / metabolism,  physiopathology
Kidney Diseases / blood,  diagnosis,  epidemiology*,  physiopathology
Logistic Models
Male
Middle Aged
Nicaragua / epidemiology
Prevalence
Risk Assessment
Risk Factors
Rural Health*
Sex Factors
Young Adult
Grant Support
ID/Acronym/Agency:
T35 DK065521- 06/DK/NIDDK NIH HHS; UL1 RR024153/RR/NCRR NIH HHS; UL1 TR000005/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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