| Niacin protects against UVB radiation-induced apoptosis in cultured human skin keratinocytes. | |
| | |
MedLine Citation:
|
PMID: 22246168 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Niacin and its related derivatives have been shown to have effects on cellular activities. However, the molecular mechanism of its reduced immunosuppressive effects and photoprotective effects remains unclear. In this study, we investigated the molecular mechanism of the photoprotective effect of niacin in ultraviolet (UV)-irradiated human skin keratinocytes (HaCaT cells). We found that niacin effectively suppressed the UV-induced cell death and cell apoptosis of HaCaT cells. Existing data have shown that AKT activation is involved in the cell survival process. Yet, the potential mechanism of niacin in protection against UV-induced skin damage has thus far not fully been eluvidated. We observed that niacin pretreatment enhances UV induced activation of AKT (Ser473 phosphorylation) as well as that of the downstream signal mTOR (S6 and 4E-BP1 phosphorylation). The PI3K/AKT inhibitor, LY294002, and the mTOR inhibitor, rapamycin, largely neutralized the protective effects of niacin, suggesting that AKT and downstream signaling mTOR/S6 activation are necessary for the niacin-induced protective effects against UV-induced cell death and cell apoptosis. Collectively, our data suggest that niacin may be utilized to prevent UV-induced skin damage and provide a novel mechanism of its photoprotective effects against the UV radiation of sunlight by modulating both AKT and downstream mTOR signaling pathways. |
| | |
Authors:
|
Fuquan Lin; Wen Xu; Cuiping Guan; Miaoni Zhou; Weisong Hong; Lifang Fu; Dongyin Liu; Aie Xu |
Related Documents
:
|
22229488 - On the redox control of b lymphocyte differentiation and function. 7541688 - Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric ... 21723158 - Signaling by the phosphatase mkp-1 in dendritic cells imprints distinct effector and re... 9831328 - Anti-inflammatory drugs and their mechanism of action. 22131328 - Eosinophils preserve parasitic nematode larvae by regulating local immunity. 7825468 - Milk proteins, cytokines and intestinal epithelial functions in children. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-12 |
Journal Detail:
|
Title: International journal of molecular medicine Volume: - ISSN: 1791-244X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9810955 Medline TA: Int J Mol Med Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou 310009, P.R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: hPRP and hydroxyapatite or natural coral combination for bone healing in rabbits: Radiological, biom...
Next Document: Calix[4]arene based 1,3,4-oxadiazole and thiadiazole derivatives: Design, synthesis, and biological ...