| Niacin: from mechanisms of action to therapeutic uses. | |
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MedLine Citation:
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PMID: 20167004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Niacin has broad spectrum lipid modifying and anti-atherosclerotic properties. It is the most effective medication available for raising raise high density lipoprotein (HDL) levels. Despite statin therapy there remains a considerable residual cardiovascular risk attributed to low HDL levels. Currently, statins decrease cardiovascular events and death by about 25-40%. Trials with surrogate endpoints have shown a decrease in endpoints by 60-90% when a combination of statin and niacin has been used. There is a growing interest in niacin in combination therapy to fill the treatment gap by modifying lipid parameters other than low density lipoprotein cholesterol. This review addresses the role of niacin in comprehensive lipid management with an emphasis on its mechanism of action, formulations, side effects, evidence from clinical trials and also focuses on practical issues related to niacin therapy. |
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Authors:
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M A Al-Mohaissen; S C Pun; J J Frohlich |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Mini reviews in medicinal chemistry Volume: 10 ISSN: 1875-5607 ISO Abbreviation: Mini Rev Med Chem Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-07-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101094212 Medline TA: Mini Rev Med Chem Country: Netherlands |
Other Details:
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Languages: eng Pagination: 204-17 Citation Subset: IM |
Affiliation:
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Healthy Heart Program, St. Paul's Hospital, Department of Pathology and Laboratory Medicine and the University of British Columbia, Vancouver BC, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Clinical Trials as Topic Drug Compounding Humans Lipoproteins, HDL / metabolism Niacin / adverse effects, metabolism*, therapeutic use Receptors, Nicotinic / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, HDL; 0/Receptors, Nicotinic; 59-67-6/Niacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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