Document Detail


Next generation adoptive immunotherapy--human T cells as carriers of therapeutic nanoparticles.
MedLine Citation:
PMID:  18283847     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An important step in adoptive immunotherapy in general and specifically with respect to cancer treatment is the initiation of an inflammatory T cell response at the tumor site. Here we suggest a new concept for a controlled inflammatory response in which the intrinsic cytotoxic properties of T cells are upgraded with the properties of nanoparticles transfected into the T cells during the ex vivo expansion process. We report in vitro upgrading of human T cells using PEGylated boron carbide nanoparticles functionalised with a translocation peptide aimed at Boron Neutron Capture Therapy (BNCT). A key finding is that the metabolism of such upgraded human T cells were not affected by a payload of 0.13 pg boron per cell and that the nanoparticles were retained in the cell population after several cell divisions. This is vital for transporting nanoparticles by T cells to the tumor site.
Authors:
M W Mortensen; L Kahns; T Hansen; P G Sorensen; O Björkdahl; M R Jensen; H J G Gundersen; T Bjørnholm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of nanoscience and nanotechnology     Volume:  7     ISSN:  1533-4880     ISO Abbreviation:  J Nanosci Nanotechnol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-02-20     Completed Date:  2008-04-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101088195     Medline TA:  J Nanosci Nanotechnol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4575-80     Citation Subset:  IM    
Affiliation:
Nano-Science Center, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Drug Carriers*
Flow Cytometry
Humans
Immunotherapy, Adoptive*
Molecular Sequence Data
Nanoparticles / therapeutic use*
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Drug Carriers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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