Document Detail


Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India.
MedLine Citation:
PMID:  23045484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The prevalence of different H. pylori genotypes in various geographical regions indicates region-specific adaptations during the course of evolution. Complete genomes of H. pylori from countries with high infection burdens, such as India, have not yet been described. Herein we present genome sequences of two H. pylori strains, NAB47 and NAD1, from India. In this report, we briefly mention the sequencing and finishing approaches, genome assembly with downstream statistics, and important features of the two draft genomes, including their phylogenetic status. We believe that these genome sequences and the comparative genomics emanating thereupon will help us to clearly understand the ancestry and biology of the Indian H. pylori genotypes, and this will be helpful in solving the so-called Indian enigma, by which high infection rates do not corroborate the minuscule number of serious outcomes observed, including gastric cancer.
Authors:
Narender Kumar; Asish K Mukhopadhyay; Rajashree Patra; Ronita De; Ramani Baddam; Sabiha Shaik; Jawed Alam; Suma Tiruvayipati; Niyaz Ahmed
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bacteriology     Volume:  194     ISSN:  1098-5530     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-09     Completed Date:  2013-01-04     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5963-4     Citation Subset:  IM    
Affiliation:
Pathogen Biology Laboratory, Department of Biotechnology, School of Life Sciences, University of Hyderabad, Gachibowli, Hyderabad, India.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AJFA00000000;  AJGJ00000000
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MeSH Terms
Descriptor/Qualifier:
Cluster Analysis
DNA, Bacterial / chemistry*,  genetics*
Duodenal Ulcer / complications,  microbiology
Gene Order*
Genome, Bacterial*
Helicobacter Infections / complications,  microbiology
Helicobacter pylori / genetics*,  isolation & purification
High-Throughput Nucleotide Sequencing*
Humans
India
Molecular Sequence Data
Phylogeny
United States
Chemical
Reg. No./Substance:
0/DNA, Bacterial
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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