| Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries. | |
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MedLine Citation:
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PMID: 22382891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been generally acknowledged that the diagnosis, treatment and prognosis evaluation of leukemia largely rely on an adequate identification of genetic abnormalities. A systemic analysis of genetic aberrations was performed in a cohort of 1346 patients with newly diagnosed acute lymphoblastic leukemia (ALL) in China. The pediatric patients had higher incidence of hyperdiploidy and t(12;21) (p13;q22)/ETV6-RUNX1 than adults (P<0.0001); in contrast, the occurrence of Ph and Ik6 variant of IKZF1 gene was much more frequent in adult patients (all P<0.0001). In B-ALL, the existence of Ik6 and that of BCR-ABL were statistically correlated (P<0.0001). In comparison with Western cohorts, the incidence of t(9;22) (q34;q11)/BCR-ABL (14.60%) in B-ALL and HOX11 expression in T-ALL (25.24%) seemed to be much higher in our group, while the incidence of t(12;21) (p13;q22)/ETV6-RUNX1 (15.34%) seemed to be lower in Chinese pediatric patients. The occurrence of hyperdiploidy was much lower either in pediatric (10.61% vs 20-38%) or adult patients (2.36% vs 6.77-12%) in our study than in Western reports. In addition, the frequencies of HOX11L2 in adult patients were much higher in our cohort than in Western countries (20.69% vs 4-11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do. |
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Authors:
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B Chen; Y-Y Wang; Y Shen; W-N Zhang; H-Y He; Y-M Zhu; H-M Chen; C-H Gu; X Fan; J-M Chen; Q Cao; G Yang; C-L Jiang; X-Q Weng; X-X Zhang; S-M Xiong; Z-X Shen; H Jiang; L-J Gu; Z Chen; J-Q Mi; S-J Chen |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-02-07 |
Journal Detail:
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Title: Leukemia Volume: 26 ISSN: 1476-5551 ISO Abbreviation: Leukemia Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-11 Completed Date: 2012-10-09 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: England |
Other Details:
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Languages: eng Pagination: 1608-16 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child China Chromosome Aberrations* Chromosome Disorders* Cohort Studies Female Humans Immunophenotyping Karyotyping Male Middle Aged Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*, genetics*, metabolism Prognosis Survival Rate Tumor Markers, Biological / genetics*, metabolism* Western World Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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