Document Detail

Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries.
MedLine Citation:
PMID:  22382891     Owner:  NLM     Status:  MEDLINE    
It has been generally acknowledged that the diagnosis, treatment and prognosis evaluation of leukemia largely rely on an adequate identification of genetic abnormalities. A systemic analysis of genetic aberrations was performed in a cohort of 1346 patients with newly diagnosed acute lymphoblastic leukemia (ALL) in China. The pediatric patients had higher incidence of hyperdiploidy and t(12;21) (p13;q22)/ETV6-RUNX1 than adults (P<0.0001); in contrast, the occurrence of Ph and Ik6 variant of IKZF1 gene was much more frequent in adult patients (all P<0.0001). In B-ALL, the existence of Ik6 and that of BCR-ABL were statistically correlated (P<0.0001). In comparison with Western cohorts, the incidence of t(9;22) (q34;q11)/BCR-ABL (14.60%) in B-ALL and HOX11 expression in T-ALL (25.24%) seemed to be much higher in our group, while the incidence of t(12;21) (p13;q22)/ETV6-RUNX1 (15.34%) seemed to be lower in Chinese pediatric patients. The occurrence of hyperdiploidy was much lower either in pediatric (10.61% vs 20-38%) or adult patients (2.36% vs 6.77-12%) in our study than in Western reports. In addition, the frequencies of HOX11L2 in adult patients were much higher in our cohort than in Western countries (20.69% vs 4-11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do.
B Chen; Y-Y Wang; Y Shen; W-N Zhang; H-Y He; Y-M Zhu; H-M Chen; C-H Gu; X Fan; J-M Chen; Q Cao; G Yang; C-L Jiang; X-Q Weng; X-X Zhang; S-M Xiong; Z-X Shen; H Jiang; L-J Gu; Z Chen; J-Q Mi; S-J Chen
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-02-07
Journal Detail:
Title:  Leukemia     Volume:  26     ISSN:  1476-5551     ISO Abbreviation:  Leukemia     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-11     Completed Date:  2012-10-09     Revised Date:  2013-03-04    
Medline Journal Info:
Nlm Unique ID:  8704895     Medline TA:  Leukemia     Country:  England    
Other Details:
Languages:  eng     Pagination:  1608-16     Citation Subset:  IM    
State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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MeSH Terms
Aged, 80 and over
Chromosome Aberrations*
Chromosome Disorders*
Cohort Studies
Middle Aged
Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis*,  genetics*,  metabolism
Survival Rate
Tumor Markers, Biological / genetics*,  metabolism*
Western World
Young Adult
Reg. No./Substance:
0/Tumor Markers, Biological

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