| Newly diagnosed acute lymphoblastic leukemia in China (II): Prognosis related to genetic abnormalities in a series of 1 091 cases. | |
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MedLine Citation:
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PMID: 22297722 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The molecular characterization of cytogenetic abnormalities has not only provided insights into the mechanisms of leukemogenesis, but also led to the establishment of new treatment strategies targeting these abnormalities, and thereby further improve the prognosis of patients. We analyzed the prognosis of 1 091 Chinese patients with newly diagnosed acute lymphoblastic leukemia (ALL) and explored the prognostic impacts of a large number of cytogenetic/molecular abnormalities. It was demonstrated that, in both B-and T-ALL settings, the prognosis was negatively correlated to the age as reported to date. For childhood T-ALL patients, it was also documented that the HOX11 expression represented a favorable prognostic factor as it was in adult ones. We identified CRLF2 overexpression as an intermediate-risk marker and Ik6 variant of IKZF1 gene as a high-risk one when stratifying pediatric B-ALL cases according to cytogenetic/molecular risks. We also found that Ik6 variant and CRLF2 overexpression played an important role in dictating the prognosis of Ph-negative patients, which may be useful markers in guiding the treatment of ALL in the future, with tyrosine kinase inhibitors on the other hand reversing the fate of Ph-positive ALL patients.Leukemia accepted article preview online, 2 February 2012; doi:10.1038/leu.2012.23. |
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Authors:
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J-Q Mi; X Wang; Y Yao; H-J Lu; X-X Jiang; J-F Zhou; J-H Wang; B Jiao; S-H Shen; J-Y Tang; L-J Gu; H Jiang; L-Y Ma; S-G Hao; F-Y Chen; S-M Xiong; Z-X Shen; Z Chen; B Chen; S-J Chen |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-02 |
Journal Detail:
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Title: Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K Volume: - ISSN: 1476-5551 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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