Document Detail


Newly developed initial-flow cell filtrometer and the comparison with viscometry and ektacytometry on erythrocyte deformability.
MedLine Citation:
PMID:  9699032     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
According to Hanss's initial-flow rate method, F. Liao designed a new cell filtrometer in the early 1990s. The parameters, cell initial transit time (Tc) and membrane clogging rate (CR), can be determined by a single measurement with timing accuracy of 1 ms. The new cell filtrometer has two valuable features: a button-pushing operation to control electromagnetic valves; and an autocirculation of fluid in the cell filtrometer resulting in the same volume of leading fluid. A series of comparisons of the new filtrometry with viscometry or ektacytometry shows that the instrument seems to be more sensitive in detecting subpopulations of glutaraldehyde-hardened cells and the shift of deformability for all the cells. The reproducibility of the filtrometer for different membranes made in China and the USA is reasonable (CV < 5% for Tc). Preliminary application of the filtrometer indicates that it might be useful for trial study and routine clinical application.
Authors:
J Peng; F L Liao; X J Yin
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  18     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  1998 Jul 
Date Detail:
Created Date:  1998-11-10     Completed Date:  1998-11-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  117-24     Citation Subset:  IM    
Affiliation:
Pharmacology Department, Chinese Institute of Materia Medica, China Academy of Traditional Chinese Medicine, Beijing, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Viscosity
Erythrocyte Deformability*
Flow Cytometry
Hemorheology / instrumentation*
Male
Rats
Rats, Wistar

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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