Document Detail

Newfoundland rod-cone dystrophy, an early-onset retinal dystrophy, is caused by splice-junction mutations in RLBP1.
MedLine Citation:
PMID:  11868161     Owner:  NLM     Status:  MEDLINE    
Some isolated populations exhibit an increased prevalence of rare recessive diseases. The island of Newfoundland is a characteristic geographic isolate, settled by a small number of families primarily during the late 1700s and early 1800s. During our studies of this population, we identified a group of families exhibiting a retinal dystrophy reminiscent of retinitis punctata albescens but with a substantially lower age at onset and more-rapid and distinctive progression, a disorder that we termed "Newfoundland rod-cone dystrophy" (NFRCD). The size of one of these families was sufficient to allow us to perform a genomewide screen to map the NFRCD locus. We detected significant linkage to markers on the long arm of chromosome 15, in a region encompassing RLBP1, the gene encoding the cellular retinaldehyde-binding protein. Previously, mutations in RLBP1 have been associated with other retinal dystrophies, leading us to hypothesize that RLBP1 mutations might also cause NFRCD. To test this hypothesis, we sequenced all coding exons and splice junctions of RLBP1. We detected two sequence alterations, each of which is likely to be pathogenic, since each segregates with the disease and is predicted to interfere with mRNA splicing. In contrast to some previously reported RLBP1 mutations, which yield a protein that may retain some residual activity, each NFRCD mutation is likely to give rise to a null allele. This difference may account for the severe phenotype in these families and exemplifies the molecular continuum that underlies clinically distinct but genetically related entities.
Erica R Eichers; Jane S Green; David W Stockton; Christopher S Jackman; James Whelan; J Arch McNamara; Gordon J Johnson; James R Lupski; Nicholas Katsanis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2002-02-26
Journal Detail:
Title:  American journal of human genetics     Volume:  70     ISSN:  0002-9297     ISO Abbreviation:  Am. J. Hum. Genet.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-08     Completed Date:  2002-04-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370475     Medline TA:  Am J Hum Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  955-64     Citation Subset:  IM    
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Data Bank Information
Bank Name/Acc. No.:
OMIM/MIM136880;  MIM180090;  MIM286000
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MeSH Terms
Age of Onset
Alternative Splicing / genetics
Base Sequence
Blindness / epidemiology,  genetics,  pathology,  physiopathology
Carrier Proteins / chemistry,  genetics*
Child, Preschool
Chromosome Mapping
DNA Mutational Analysis
Dark Adaptation / genetics
Haplotypes / genetics
Lod Score
Middle Aged
Mutation / genetics*
Newfoundland and Labrador / epidemiology
RNA Splice Sites / genetics*
Retinitis Pigmentosa / epidemiology*,  genetics*,  pathology,  physiopathology
Visual Fields / genetics
Grant Support
Reg. No./Substance:
0/11-cis-retinal-binding protein; 0/Carrier Proteins; 0/RNA Splice Sites

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