Document Detail


Newer trends in the management of genital herpes.
MedLine Citation:
PMID:  19915235     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Management of genital herpes is complex. Apart from using the standard antivirals, an ideal management protocol also needs to address various aspects of the disease, including the psychological morbidity. Oral acyclovir, valacyclovir or famciclovir are recommended for routine use. Long-term suppressive therapy is effective in reducing the number of recurrences and the risk of transmission to others. Severe or disseminated disease may require intravenous therapy. Resistant cases are managed with foscarnet or cidofovir. Genital herpes in human immunodeficiency virus-infected individuals usually needs a longer duration of antiviral therapy along with continuation of highly active anti retroviral therapy (HAART). Genital herpes in late pregnancy increases the risk of neonatal herpes. Antiviral therapy and/or cesarean delivery are indicated depending on the clinical circumstance. Acyclovir appears to be safe in pregnancy. But, there is limited data regarding the use of valacyclovir and famciclovir in pregnancy. Neonatal herpes requires a higher dose of acyclovir given intravenously for a longer duration. Management of the sex partner, counseling and prevention advice are equally important in appropriate management of genital herpes. Vaccines till date have been marginally effective. Helicase-primase inhibitors, needle-free mucosal vaccine and a new microbicide product named VivaGel may become promising treatment options in the future.
Authors:
Amiya Kumar Nath; Devinder Mohan Thappa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian journal of dermatology, venereology and leprology     Volume:  75     ISSN:  0973-3922     ISO Abbreviation:  Indian J Dermatol Venereol Leprol     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-11-16     Completed Date:  2010-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7701852     Medline TA:  Indian J Dermatol Venereol Leprol     Country:  India    
Other Details:
Languages:  eng     Pagination:  566-74     Citation Subset:  IM    
Affiliation:
Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry - 605 006, India.
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / therapeutic use*
Communicable Disease Control / statistics & numerical data*
Female
Herpes Genitalis / drug therapy*,  epidemiology,  prevention & control*
Humans
India / epidemiology
Pregnancy
Pregnancy Complications, Infectious / drug therapy,  prevention & control
Risk Factors
Chemical
Reg. No./Substance:
0/Antiviral Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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