| Newer trends in the management of genital herpes. | |
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MedLine Citation:
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PMID: 19915235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Management of genital herpes is complex. Apart from using the standard antivirals, an ideal management protocol also needs to address various aspects of the disease, including the psychological morbidity. Oral acyclovir, valacyclovir or famciclovir are recommended for routine use. Long-term suppressive therapy is effective in reducing the number of recurrences and the risk of transmission to others. Severe or disseminated disease may require intravenous therapy. Resistant cases are managed with foscarnet or cidofovir. Genital herpes in human immunodeficiency virus-infected individuals usually needs a longer duration of antiviral therapy along with continuation of highly active anti retroviral therapy (HAART). Genital herpes in late pregnancy increases the risk of neonatal herpes. Antiviral therapy and/or cesarean delivery are indicated depending on the clinical circumstance. Acyclovir appears to be safe in pregnancy. But, there is limited data regarding the use of valacyclovir and famciclovir in pregnancy. Neonatal herpes requires a higher dose of acyclovir given intravenously for a longer duration. Management of the sex partner, counseling and prevention advice are equally important in appropriate management of genital herpes. Vaccines till date have been marginally effective. Helicase-primase inhibitors, needle-free mucosal vaccine and a new microbicide product named VivaGel may become promising treatment options in the future. |
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Authors:
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Amiya Kumar Nath; Devinder Mohan Thappa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Indian journal of dermatology, venereology and leprology Volume: 75 ISSN: 0973-3922 ISO Abbreviation: Indian J Dermatol Venereol Leprol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-16 Completed Date: 2010-02-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7701852 Medline TA: Indian J Dermatol Venereol Leprol Country: India |
Other Details:
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Languages: eng Pagination: 566-74 Citation Subset: IM |
Affiliation:
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Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research , Pondicherry - 605 006, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiviral Agents
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therapeutic use* Communicable Disease Control / statistics & numerical data* Female Herpes Genitalis / drug therapy*, epidemiology, prevention & control* Humans India / epidemiology Pregnancy Pregnancy Complications, Infectious / drug therapy, prevention & control Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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