Document Detail

Newer concepts and approaches to neonatal brain asphyxia.
MedLine Citation:
PMID:  10771947     Owner:  NLM     Status:  MEDLINE    
The asphyxial injury to neonate brain seems to be mediated through a cascade of biochemical events during ischaemia--reperfusion which includes excitatory amino acids, free radicals and accelerated programmed cell death (Apoptosis). The diagnosis of asphyxia requires rigorous approach based on background clinical information, certain diagnostic tests and exclusion of alternative diagnosis which may have similar clinical presentation. The treatment currently employed for the management of birth asphyxia controversial and requires critical appraisal. The future strategies for management include a number of approaches based on putative mechanism for asphyxial brain injury but they are still being evaluated as research and should not be used for clinical purposes in human newborns as yet.
S K Sinha; J Singh
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  65     ISSN:  0019-5456     ISO Abbreviation:  Indian J Pediatr     Publication Date:    1998 Jan-Feb
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  55-62     Citation Subset:  IM    
Division of Women and Children, South Cleveland Hospital, Middlesbrough, UK.
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MeSH Terms
Apoptosis / physiology
Asphyxia Neonatorum / physiopathology,  therapy*
Brain / blood supply
Brain Damage, Chronic / physiopathology,  therapy
Excitatory Amino Acids / physiology
Free Radicals / metabolism
Hypoxia, Brain / physiopathology,  therapy*
Infant, Newborn
Reperfusion Injury / physiopathology,  therapy
Reg. No./Substance:
0/Excitatory Amino Acids; 0/Free Radicals

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