Document Detail

Newer anticoagulants as an alternate to warfarin in atrial fibrillation: a changing paradigm.
MedLine Citation:
PMID:  20460986     Owner:  NLM     Status:  In-Data-Review    
Atrial fibrillation is the most common cardiac arrhythmia responsible for one third of the hospitalizations because of cardiac rhythm disturbances. Atrial fibrillation leads to stroke, heart failure, and other causes of mortality. Warfarin, a vitamin K antagonist, is the first-line agent for the prophylaxis of stroke in patients with atrial fibrillation. Limitations associated with warfarin have led to development of new anticoagulants targeting different sites in the coagulation cascade. A direct thrombin inhibitor, dabigatran, has been evaluated in clinical studies for prophylaxis in atrial fibrillation. Factor Xa inhibitors, direct as well as indirect inhibitors, are in various stages of development for their antithrombotic effect. This article reviews the studies done on these novel anticoagulants and their prophylactic potential for the prevention of stroke in atrial fibrillation.
Dhara Chaudhari; Rohit Bhuriya; Rohit Arora
Related Documents :
15286936 - Arrhythmias of a sudden traumatic death.
8950056 - Role of echocardiography in the evaluation and management of atrial fibrillation.
14503426 - Incidence, timing, symptoms, and risk factors for atrial fibrillation after cardiac sur...
9139946 - Autonomic modulation of ventricular rate in atrial fibrillation.
8502976 - Patterns of vascular pathology in acute, first-ever cerebral infarction.
21734556 - Cardiopulmonary bypass techniques and clinical outcomes in beijing fuwai hospital: a br...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of therapeutics     Volume:  18     ISSN:  1536-3686     ISO Abbreviation:  Am J Ther     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2012-05-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1-e11     Citation Subset:  IM    
1B. J. Medical College, Ahmedabad, India; and 2Division of Cardiology, Department of Medicine, The Chicago Medical School, North Chicago, IL.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Parenteral bisphosphonates for osteoporosis in patients with primary biliary cirrhosis.
Next Document:  Prediction of Postoperative Pain: A Systematic Review of Predictive Experimental Pain Studies.