Document Detail


Newborn rats in the murine typhus enzootic infection cycle: studies on transplacental infection and passively acquired maternal antirickettsial antibodies.
MedLine Citation:
PMID:  3142287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study focused attention on the newborn rat as a possible significant participant in the highly successful enzootic cycle of murine typhus. We examined the influence of maternal Rickettsia typhi (R. mooseri) infection in rats on the offspring with respect to the possible vertical transmission of R. typhi and the passive transfer of maternal antirickettsial antibodies. Transmission of R. typhi by rickettsemic pregnant rats did not occur either transplacentally during gestation to their fetuses or postnatally through colostrum and milk to their newborn. The rickettsial burden of the placenta was sometimes greater than 10(6) plaque forming units per g tissue and undetectable in colostrum or milk. However, newborn rats were highly susceptible to infection per os. Transplacental passage of antirickettsial antibody to offspring was detectable only when the mother's antibody titer was high. Passive postpartum acquisition of antirickettsial antibodies by newborn rats from colostrum and milk of immune mothers occurred regardless of the height of the maternal antibody titer, rose to a maximum at about 3 weeks of age, and then declined rapidly, becoming undetectable 4 weeks after birth.
Authors:
S Arango-Jaramillo; C L Wisseman; A F Azad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  39     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-11-25     Completed Date:  1988-11-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  391-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore 21201.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Antibodies, Bacterial / analysis
Colostrum / immunology
Female
Immunity, Maternally-Acquired*
Maternal-Fetal Exchange
Mice
Milk / immunology
Pregnancy
Pregnancy Complications, Infectious / immunology,  veterinary
Rats
Rats, Inbred Strains*
Rickettsia typhi / immunology
Rodent Diseases / immunology,  transmission*
Typhus, Endemic Flea-Borne / immunology,  transmission,  veterinary*
Grant Support
ID/Acronym/Agency:
AI 17828/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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