Document Detail

Newborn jaundice technologies: unbound bilirubin and bilirubin binding capacity in neonates.
MedLine Citation:
PMID:  21641486     Owner:  NLM     Status:  MEDLINE    
Neonatal jaundice (hyperbilirubinemia), which is extremely common in neonates, can be associated with neurotoxicity. A safe level of bilirubin has not been defined in either premature or term infants. Emerging evidence suggest that the level of unbound (or "free") bilirubin has a better sensitivity and specificity than total serum bilirubin for bilirubin-induced neurotoxicity. Although recent studies suggest the usefulness of free bilirubin measurements in managing high-risk neonates, including premature infants, no widely available method exists to assay the serum free bilirubin concentration. To keep pace with the growing demand, in addition to reevaluation of old methods, several promising new methods are being developed for sensitive, accurate, and rapid measurement of free bilirubin and bilirubin binding capacity. These innovative methods need to be validated before adopting for clinical use. We provide an overview of some promising methods for free bilirubin and binding capacity measurements with the goal to enhance research in this area of active interest and apparent need.
Sanjiv B Amin; Angelo A Lamola
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  35     ISSN:  1558-075X     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-06     Completed Date:  2012-03-15     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  134-40     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
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MeSH Terms
Bilirubin / blood*,  metabolism
Fluorometry / methods
Infant, Newborn
Jaundice, Neonatal / blood*
Serum Albumin / metabolism*
Spectrophotometry / methods
Grant Support
1R21DEO21161//PHS HHS; K-23 DC 006229/DC/NIDCD NIH HHS; K23 DC006229/DC/NIDCD NIH HHS; K23 DC006229-06/DC/NIDCD NIH HHS; R03 HD061084/HD/NICHD NIH HHS; R03 HD061084/HD/NICHD NIH HHS; R03 HD061084-01/HD/NICHD NIH HHS; R21 DE021161/DE/NIDCR NIH HHS; R21 DE021161-01/DE/NIDCR NIH HHS
Reg. No./Substance:
0/Serum Albumin; 0/albumin-bilirubin complex; RFM9X3LJ49/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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