Document Detail


Newborn vitamin A supplementation does not affect nasopharyngeal carriage of Streptococcus pneumoniae in Bangladeshi infants at age 3 months.
MedLine Citation:
PMID:  21832026     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nasopharyngeal (NP) carriage of S. pneumoniae (Spn) is a risk factor for pneumococcal disease and its transmission. We assessed the impact of vitamin A (VA) supplementation shortly after birth in reducing Spn colonization in early infancy in rural Bangladesh. We recruited 500 infants participating in a cluster-randomized trial that reported a 15% reduction in mortality following receipt of an oral dose of VA (52.25 μmol) compared to placebo. NP specimens were collected at the age of 3 mo to study the effect of VA on the prevalence of culture-confirmed Spn. Analyses were conducted by intention to treat. Spn carriage prevalence did not differ between VA and placebo recipients [OR = 0.83 (95% CI: 0.55-1.27); P = 0.390]. Spn carriage at the age of 3 mo was not lowered by VA given at birth. Results are similar to those from an Indian study in which impact on Spn carriage was assessed at the age of 4 mo [OR = 0.73 (95% CI: 0.48-1.10); P = 0.128]. The point estimate of the pooled effect size for the 2 studies is OR = 0.78 [(95% CI: 0.58-1.04); P = 0.095], which may imply a modest impact on carriage. If so, then the evidence thus far would suggest that Spn carriage reduction is unlikely to be a primary ancillary benefit of newborn VA supplementation.
Authors:
Christian L Coles; Alain Labrique; Samir K Saha; Hasmot Ali; Hassan Al-Emran; Mahbubur Rashid; Parul Christian; Keith P West; Rolf Klemm
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-10
Journal Detail:
Title:  The Journal of nutrition     Volume:  141     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-09-21     Completed Date:  2011-11-18     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1907-11     Citation Subset:  IM    
Affiliation:
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. ccoles@jhsph.edu
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00128557
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MeSH Terms
Descriptor/Qualifier:
Bangladesh / epidemiology
Carrier State / epidemiology,  prevention & control*
Cohort Studies
Developing Countries
Dietary Supplements*
Double-Blind Method
Drug Resistance, Viral
Early Termination of Clinical Trials
Female
Humans
Infant, Newborn
Male
Nasopharynx / virology*
Pneumonia, Pneumococcal / prevention & control
Prevalence
Rural Health
Serotyping
Streptococcus pneumoniae / classification,  drug effects,  isolation & purification*
Vitamin A / therapeutic use*
Grant Support
ID/Acronym/Agency:
K01DK07578/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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