Document Detail

Newborn TSH concentration and its association with cognitive development in healthy boys.
MedLine Citation:
PMID:  20829366     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: An association between thyroid function during pregnancy or infancy and neurodevelopment in children has been demonstrated. We aimed to investigate whether newborn TSH concentrations are related to subsequent neurocognitive development.
DESIGN: We conducted a longitudinal study on 178 children from a general population birth cohort in Granada (Spain) born in 2000-2002.
METHODS: TSH concentrations were measured in umbilical cord blood, and cognitive functions were assessed at 4 years of age using the McCarthy's scales of children's abilities (MSCA). Organochlorine (OC) compound concentrations and the combined oestrogenicity (total effective xeno-oestrogenic burden (TEXB)) were also determined in the placentae.
RESULTS: Mean newborn TSH was 3.55  mU/l (range=0.24-17 mU/l). In multivariate regression analyses, adjusting for maternal and child characteristics, higher newborn TSH concentrations showed a decrease of 3.51 and 3.15 points on the MSCA general cognitive and executive function scores respectively and were associated with a higher risk of scoring below the 20th percentile (P20) on the quantitative score (odds ratio (OR)=2.64). Children with TSH in the upper quartile (4.19-17.0 mU/l) were at higher risk of scoring <P20 on span memory (OR=5.73), whereas children with TSH in the second quartile (2.05-2.95 mU/l) were at lower risk of scoring <P20 on the verbal scale (OR=0.24). Neonatal TSH status was also associated with general cognitive and executive function outcomes when controlling for prenatal exposure to OCs or placental TEXB.
CONCLUSIONS: Newborn thyroid hormone status expressed by TSH in cord blood may adversely affect later cognitive function. A more thorough screening for neonatal thyroid deficiency is warranted.
Carmen Freire; Rosa Ramos; Esperanza Amaya; Mariana F Fernández; Piedad Santiago-Fernández; Maria-Jose Lopez-Espinosa; Juan-Pedro Arrebola; Nicolas Olea
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2010-09-09
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  163     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-11     Completed Date:  2010-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  901-9     Citation Subset:  IM    
Laboratory of Medical Investigations, San Cecilio University Hospital, University of Granada, CIBER de Epidemiología y Salud Pública (CIBERESP), Avenida Madrid s/n, 18071 Granada, Spain.
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MeSH Terms
Child, Preschool
Endocrine Disruptors / adverse effects
Fetal Blood / chemistry
Hydrocarbons, Chlorinated / toxicity
Infant, Newborn / blood*
Placenta / chemistry
Prenatal Exposure Delayed Effects
Prospective Studies
Thyrotropin / blood*
Reg. No./Substance:
0/Endocrine Disruptors; 0/Hydrocarbons, Chlorinated; 9002-71-5/Thyrotropin

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