| Newborn Screening Shows a High Incidence of Sickle Cell Anemia in Central India. | |
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MedLine Citation:
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PMID: 22712682 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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There is limited data on the incidence of sickle cell anemia in Central India; we therefore conducted a study to estimate the incidence of this disease in Central India. Mothers who delivered a live baby at the Government Medical College, Nagpur, India were screened for the presence of the sickle cell hemoglobin {Hb S: [β6 (A3) Glu →Val, GAG >GTG]} using the solubility test within 48 hours of delivery. Infants of mothers who showed the presence of Hb S then underwent Hb analysis by high performance liquid chromatography (HPLC). A total of 8243 mothers was screened, 1178 of whom were positive. One thousand, one hundred and sixty-two infants of mothers with a positive solubility test underwent Hb analysis by HPLC; 530 infants were normal, while 536 were heterozygous for Hb S (sickle cell trait), 88 babies were homozygous for Hb S (sickle cell anemia), while another eight babies had other Hb abnormalities. The incidence of sickle cell anemia was highest in the Scheduled caste group (1:50). We concluded that the incidence of sickle cell anemia is high in central India. |
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Authors:
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Dipty L Jain; Vijaya Sarathi; Dipty Upadhye; Rohini Gulhane; Anita H Nadkarni; Kanjaksha Ghosh; Roshan B Colah |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-19 |
Journal Detail:
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Title: Hemoglobin Volume: - ISSN: 1532-432X ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705865 Medline TA: Hemoglobin Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Paediatrics, Government Medical College , Nagpur-440009 , India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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