Document Detail


The Newborn Lamb as A New Model For Studying Gastroesophageal Reflux.
MedLine Citation:
PMID:  22722679     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT: We aimed to determine whether the newborn lamb at term is a valid model for studying gastroesophageal reflux. Seven bottle-fed lambs, aged 2-3 days, underwent esophageal Multichannel Intraluminal Impedance-pH monitoring (MII-pH). A total of 196 reflux episodes were recorded, including 73% alkaline and 27% weakly acid. No acid refluxes were observed. Median bolus clearance time was 4 s [3; 5.5], and proximal reflux extent was 35% (26). This first report of MII-pH in the newborn mammal sets the foundations for future studies with physiological and clinical relevance to human neonates.
Authors:
Djamal Djeddi; Nathalie Samson; Nadia Boudaa; Jean-Paul Praud
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-19
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  -     ISSN:  1536-4801     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Neonatal Respiratory Research Unit, Department of Pediatrics and Physiology, Université de Sherbrooke, QC, Canada, J1H 5N4.
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