Document Detail


New xenograft valved conduit (Contegra) for right ventricular outflow tract reconstruction.
MedLine Citation:
PMID:  14721819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The well-known flaws of existing valved conduits for reconstruction of the right ventricular outflow tract (RVOT) continue to stimulate research for the elusive "perfect" conduit. In this study, we describe our experience with a glutaraldehyde-treated bovine jugular vein valved conduit (Contegra). METHODS: 55 years underwent implantation of a Contegra conduit. Diagnoses/procedures included repair of truncus arteriosus (2 patients), pulmonary atresia (3 patients), severe pulmonary insufficiency after prior repair of tetralogy of Fallot (9 patients), and replacement of degenerated valved conduit (1 patient). RESULTS: No operative deaths occurred. One patient required an early conduit replacement for unexplained valve thrombosis. The early postoperative mean transconduit pressure gradient was 7.7+/- 4.9 mm Hg. At a mean follow-up time of 18.5 +/- 6.9 months, all patients were asymptomatic with no discernible calcification in the valve or conduit or significant valve incompetence, while the mean transvalvular gradient remained low (11.1 +/- 4.5 mm Hg). CONCLUSION: The Contegra valved conduit is well suited for RVOT reconstruction, avoids the use of additional foreign material, and remains well functioning during early followup. Nonetheless, the long-term durability remains to be ascertained.
Authors:
Andrew C Chatzis; Nicolas M Giannopoulos; Demetrios Bobos; George B Kirvassilis; Spyros Rammos; George E Sarris
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The heart surgery forum     Volume:  6     ISSN:  1522-6662     ISO Abbreviation:  Heart Surg Forum     Publication Date:  2003  
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-05-04     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  100891112     Medline TA:  Heart Surg Forum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  396-8     Citation Subset:  IM    
Affiliation:
Department of Paediatric and Congenital Heart Surgery, Onassis Cardiac Surgery Centre, Athens, Greece. achatzis@otenet.gr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Bioprosthesis*
Cattle
Child
Child, Preschool
Female
Heart Valve Diseases / surgery
Humans
Infant
Jugular Veins / transplantation*
Male
Middle Aged
Postoperative Complications / surgery
Pulmonary Valve Insufficiency / surgery*
Reoperation
Tetralogy of Fallot / surgery*
Thrombosis / surgery
Transplantation, Heterologous
Ventricular Outflow Obstruction / surgery*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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