Document Detail

New vistas for leucovorin in cancer chemotherapy.
MedLine Citation:
PMID:  2645044     Owner:  NLM     Status:  MEDLINE    
With a resurgence of interest in leucovorin calcium (LV), many questions about its role in cancer chemotherapy are being asked again. How does it modulate 5-fluorouracil (5-FU) therapy? Can it potentiate the cytotoxicity of 5-FU more in malignant than in normal cells? Does it rescue tumor cells from high-dose methotrexate (MTX) more than it does normal cells? How should LV rescue be individualized to maximize the therapeutic index? When can LV be administered orally, and how can LV rescue be conducted at home? When is LV rescue necessary, and what toxicities occur when it is inadequate? Some answers to these questions are provided in this review.
W A Bleyer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cancer     Volume:  63     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-04-05     Completed Date:  1989-04-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  995-1007     Citation Subset:  AIM; IM    
University of Washington School of Medicine, Seattle 98105.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Chemical Phenomena
Fluorouracil / administration & dosage
Leucovorin / administration & dosage,  pharmacology*
Methotrexate / administration & dosage
Neoplasms / drug therapy*
Reg. No./Substance:
51-21-8/Fluorouracil; 58-05-9/Leucovorin; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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