| New ursane-type triterpene with NO production suppressing activity from Nauclea officinalis. | |
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MedLine Citation:
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PMID: 22296148 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Two new ursane-type triterpenes, named as 3β, 19α, 23, 24-tetrahydroxyurs-12-en-28-oic acid (1) and 2β, 3β, 19α, 24-tetrahydroxyurs-12-en-28-oic acid (2), together with two known triterpenoids, 3-oxo-urs-12-ene-27, 28-dioic acid (3) and quinovic acid-3-β-rhamnopyranoside (4), were isolated from the stems (with barks) of Nauclea officinalis. The structures of 1 and 2 were determined by the combined use of single-crystal X-ray diffraction and spectroscopic data analysis. The inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in mouse macrophage RAW 264.7 cells were examined, and compound 1 was found to inhibit NO production, with the IC(50) value of 4.8 μM. |
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Authors:
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Jia-Yi Tao; Sheng-Jun Dai; Feng Zhao; Jun-Feng Liu; Wei-Shuo Fang; Ke Liu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of Asian natural products research Volume: 14 ISSN: 1477-2213 ISO Abbreviation: J Asian Nat Prod Res Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888334 Medline TA: J Asian Nat Prod Res Country: England |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: IM |
Affiliation:
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a Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , 100050 , China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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