Document Detail


New tyrosine metabolites in humans: hawkinsin and cis- and trans-4-hydroxycyclohexylacetic acids. Unusual adsorption of deuterated and non-deuterated hawkinsin during gas chromatography.
MedLine Citation:
PMID:  701419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a new inborn error of metabolism, where obviously a defect of 4-hydroxyphenylpyruvate dioxygenase (EC 1.13.11.27) exists, hawkinsin [(2-cystein-S-yl-1,4-dihydroxycyclohex-5-en-1-yl) acetic acid] and cis- and trans-hydroxycyclohexylacetic acids were found in the urine. A partially reversible adsorption of deuterated and non-deuterated hawkinsin (as the penta-trimethylsilyl derivative) in gas chromatography--mass spectrometry has inhibited a mass fragmentographic quantitation of this compound to date. However, quantitation seems to be possible using mass framentography of 1,4-dihydroxycyclohexylacetic acid, formed by desulfuration of the sample with active nickel.
Authors:
A Niederwieser; A Matasović; F Neuheiser; E Wetzel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of chromatography     Volume:  146     ISSN:  -     ISO Abbreviation:  J. Chromatogr.     Publication Date:  1978 Sep 
Date Detail:
Created Date:  1978-12-29     Completed Date:  1978-12-29     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0427043     Medline TA:  J Chromatogr     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  207-12     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adsorption
Amino Acids, Sulfur / analysis*
Chromatography, Gas
Cyclohexanecarboxylic Acids / analysis
Mass Spectrometry
Stereoisomerism
Chemical
Reg. No./Substance:
0/Amino Acids, Sulfur; 0/Cyclohexanecarboxylic Acids

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